Ceddanne Rafaela went 4-for-4 with seven RBIs while Masataka Yoshida also had four hits and three runs scored as the host Boston Red Sox cruised past the Chicago Cubs 17-0 on Saturday.

The Red Sox totaled a season-high 21 hits while scoring six runs in both the fifth and eighth innings. Tyler O'Neill added a 3-for-5 performance including a home run and two RBIs, and Bobby Dalbec drove in three runs and scored two more.

Justin Slaten (2-0) earned the win in relief, pitching 1-2-3 innings in the fifth and sixth.

Boston starter Josh Winckowski stranded two runners to post a first-inning zero and send his offense to the plate. O'Neill, hitting third, staked the Red Sox to a 2-0 lead with a two-run homer over the Green Monster against Chicago's Ben Brown (0-1) to begin the rout.

Yankees 15, Brewers 3

Alex Verdugo drove in four runs and left-hander Carlos Rodon threw six innings as New York routed host Milwaukee in the second of a three-game series.

The Yankees posted season highs in both runs and hits (19) in winning for the sixth time in their last 10 games. Anthony Rizzo, Aaron Judge and Giancarlo Stanton also homered. Rodon (2-1) allowed just one run, walked one and struck out eight in a 93-pitch effort in getting the win.

Rhys Hoskins hit his sixth homer for the Brewers, who lost for just the third time in 10 games. Joe Ross (1-3) needed 99 pitches to get through five innings, giving up eight hits and seven runs (six earned) with three walks and five strikeouts.

White Sox 8, Rays 7 (10 innings)

Andrew Benintendi went 3-for-5 with six RBIs and drilled a game-ending two-run home run in the 10th inning to propel host Chicago to a victory over Tampa Bay.

Benintendi connected against Phil Maton (0-2), who blew the save after the Rays scored a run against Deivi Garcia (1-2) in the top half of the 10th. The White Sox have won consecutive games for the first time this season while securing their first series win.

Eloy Jimenez and Tommy Pham had two hits apiece for Chicago. Richie Palacios and Ben Rortvedt each had three hits for the Rays.

Mariners 3, Diamondbacks 1

George Kirby pitched seven scoreless innings and struck out a career-high 12 batters as Seattle defeated visiting Arizona in an interleague game.

Ty France hit a two-run homer for the American League West-leading Mariners, who won their third game in a row and for the ninth time in their past 11. Kirby (3-2) allowed two hits and one base on balls.

Arizona rookie Slade Cecconi (1-1), starting in place of the injured Merrill Kelly, nearly matched Kirby. The righty went six innings and gave up just one run on three hits, with one walk and a career-high eight strikeouts.

Dodgers 4, Blue Jays 2

Mookie Betts had three hits, one RBI and a stolen base, right-hander Tyler Glasnow struck out nine and visiting Los Angeles defeated Toronto.

The Dodgers have won the first two games of the three-game series. They are 5-0 to open a nine-game road trip and have won six in a row overall. Glasnow (5-1) allowed one run, two hits and three walks in six-plus innings. He left the game with cramps.

The Blue Jays have lost five in a row, including the first two games of a six-game homestand. Toronto left-hander Yusei Kikuchi (2-2) allowed four runs, nine hits and no walks with three strikeouts in six innings.

Cardinals 7, Mets 4

Paul Goldschmidt hit a two-run double in a four-run first inning as St. Louis topped host New York.

Cardinals third baseman Nolan Arenado hit an RBI single in the opening frame against Mets starter Adrian Houser (0-3) and reached base for a 25th straight game. Arenado also avoided a potentially scary injury in the seventh when he fouled a ball off his face in the area above his nose and near his forehead.

Pete Alonso hit his 200th career homer in the loss. He joined Darryl Strawberry, Mike Piazza and David Wright as the fourth player to hit 200 home runs with the Mets.

Nationals 11, Marlins 4

Jesse Winker hit a grand slam and Keibert Ruiz and Nick Senzel each added solo shots as Washington scored a season high in runs and hammered host Miami.

No. 9 hitter Jacob Young bundled two hits, one RBI, two stolen bases and four runs scored for Washington, which has won the first two of the teams' four-game series.

Jacob Barnes (1-0) pitched two scoreless innings for Washington in relief of starter Mitchell Parker, who allowed one run on six hits while striking out two and walking two over four innings.

Orioles 7, Athletics 0

Cole Irvin pitched seven shutout innings and Adley Rutschman and Ryan Mountcastle hit back-to-back solo home runs as host Baltimore defeated Oakland.

Gunnar Henderson added a two-run homer as the Orioles cranked up their power numbers after a slight decline in that area. It was his third homer in four games and ninth for the season. Irvin (2-1) limited the Athletics to four hits while striking out five without a walk. Mike Baumann and Dillon Tate each pitched an inning to complete the five-hitter.

JP Sears worked 6 1/3 innings for the Athletics, allowing seven runs on eight hits. He struck out eight and issued his only walk in the seventh.

Tigers 6, Royals 5

Matt Vierling hit a three-run homer as part of a five-run seventh inning to lift Detroit over visiting Kansas City.

Vierling's two-out home run to left-center off Kansas City reliever Chris Stratton (2-2) capped the Tigers' comeback after they trailed 3-1 going into the seventh.

Kansas City scored two runs in the ninth inning off Detroit closer Jason Foley to trim its deficit to 6-5, but Vinnie Pasquantino flied out to center field with Bobby Witt Jr. on first base to end the game.

Reds 8, Rangers 4

Hunter Greene allowed one hit over seven shutout innings and Jonathan India went 4-for-4 with a home run and four RBIs to lead visiting Cincinnati over Texas.

It was the first win in six starts this season for Greene (1-2), who walked one and struck out six. Will Benson also homered and had two hits for the Reds, who snapped a two-game losing streak.

Davis Wendzel hit his first major league home run, Josh Smith had two doubles and an RBI and Corey Seager also homered for the Rangers. Michael Lorenzen (2-1) suffered the loss allowing five runs on six hits over six-plus innings. He walked one, struck out three and also hit a pair of batters.

Guardians 4, Braves 2 (11 innings)

Josh Naylor doubled home the go-ahead run and pinch-hitter Ramon Laureano added a sacrifice fly in the 11th inning to help visiting Cleveland defeat Atlanta, ending the Braves' four-game winning streak.

Scott Barlow (2-2) held the Braves scoreless in the bottom of the 10th inning and Nick Sandlin came in in the 11th to get the save and square the three-game series at one game apiece. The losing pitcher was Dylan Lee (0-1).

Neither starting pitcher figured in the decision despite each pitching seven scoreless innings. Cleveland's Tanner Bibee allowed two hits, no walks and matched his career high with nine strikeouts. Atlanta's Charlie Morton went a season-long seven innings, gave up four hits, one walk and struck out six.

Twins 16, Angels 5

Carlos Santana went 2-for-4 with a double, a homer and four RBIs, and Minnesota cruised past the host Angels in Anaheim, Calif.

Santana homered for the third game in a row for Minnesota, which won its sixth straight contest. Edouard Julien went 3-for-5 with a double and three RBIs, and Max Kepler finished 2-for-4 with a homer and two RBIs.

Jo Adell went 3-for-4 with a homer and three RBIs to lead the Angels, who lost for the eighth time in their past nine games. Angels right-hander Jose Soriano (0-4) gave up four runs on three hits in 1 2/3 innings. He walked three and struck out one.

Astros 12, Rockies 4

Yordan Alvarez homered twice and finished with three hits, Kyle Tucker also went deep and Houston routed Colorado in the first game of the Mexico City Series.

Yainer Diaz had three hits and three runs and Tucker, Mauricio Dubon and Jose Abreu each finished with two hits in the win. Ronel Blanco (3-0) allowed two runs on five hits and two walks, striking out eight, in 5 2/3 innings for Houston, which snapped a five-game skid.

Ryan McMahon homered and Nolan Jones had two hits for Colorado. Cal Quantrill allowed six runs on six hits and two walks in five-plus innings.

Phillies 5, Padres 1

Ranger Suarez threw eight brilliant innings and Alec Bohm drove in four runs as visiting Philadelphia cruised past San Diego.

Suarez (5-0) gave up three hits and a run with no walks and eight strikeouts for the Phillies. The only blemish was Eguy Rosario's third homer of the year with two outs in the bottom of the eighth inning.

Padres starter Dylan Cease (3-2) suffered his first loss since March 30, lasting six innings and allowing five runs on six hits and three walks. Cease fanned five.

Pirates 4, Giants 3 (10 innings)

Bryan Reynolds hit a two-run home run and Ke'Bryan Hayes followed with a solo shot in the top of the 10th inning, lifting visiting Pittsburgh over San Francisco.

Reynolds, Hayes and Connor Joe each had two hits for the Pirates, who outhit the Giants 11-7 en route to snapping a three-game losing streak.

Patrick Bailey had a pair of singles for the Giants, who lost for the second time in their past five games.