

| On IR - Designated For Return: | |||
| Trey Benson | |||
| Questionable: | |||
| Marvin Harrison Jr. | Illness | ||
| Zonovan Knight | Knee | ||
| Max Melton | Heel | ||
| Out: | |||
| Emari Demercado | Ankle | ||
| Walter Nolen II | Knee | ||
| Dadrion Taylor-Demerson | Ankle | ||
| Out: | |||
| Drake London | Knee | ||
| Josh Woods | Hamstring | ||
| On IR: | |||
| Taven Bryan | |||
| Justice Hill | |||
| On IR: | |||
| Curtis Samuel | |||
| Questionable: | |||
| Dalton Kincaid | Hamstring | ||
| Josh Palmer | Ankle | ||
| Out: | |||
| Terrel Bernard | Elbow | ||
| Out: | |||
| Claudin Cherelus | Concussion | ||
| Jaycee Horn | Concussion | ||
| Christian Rozeboom | Hip | ||
| Out: | |||
| T.J. Edwards | Hand | ||
| Questionable: | |||
| Jerome Ford | Hamstring | ||
| Out: | |||
| Brenden Bates | Ankle | ||
| Adin Huntington | Quad | ||
| Alex Wright | Quad | ||
| Questionable: | |||
| Caelen Carson | Hamstring | ||
| On IR - Designated For Return: | |||
| Josh Paschal | |||
| Questionable: | |||
| Terrion Arnold | Concussion | ||
| Marcus Davenport | Shoulder | ||
| Isaac TeSlaa | Hand | ||
| Sione Vaki | Ankle | ||
| Out: | |||
| Kerby Joseph | Knee | ||
| Kalif Raymond | Ankle | ||
| Brock Wright | Neck | ||
| On IR - Designated For Return: | |||
| Jayden Reed | |||
| Questionable: | |||
| Matthew Golden | Wrist | ||
| Nate Hobbs | Knee | ||
| Keisean Nixon | Neck | ||
| Quay Walker | Neck | ||
| Out: | |||
| Karl Brooks | Ankle | ||
| Lukas Van Ness | Foot | ||
| Savion Williams | Foot | ||
| Out: | |||
| Jamal Hill | Hamstring | ||
| On IR - Designated For Return: | |||
| Jaylon Carlies | |||
| On IR - Designated For Return: | |||
| Eric Murray | |||
| Out: | |||
| Travon Walker | Knee | ||
| Out: | |||
| Noah Gray | Concussion | ||
| Questionable: | |||
| Poona Ford | Calf | ||
| Kamren Kinchens | Shoulder | ||
| Questionable: | |||
| Adam Butler | Illness | ||
| Darnay Holmes | Illness | ||
| Zamir White | Illness | ||
| Out: | |||
| Michael Mayer | Ankle | ||
| On IR: | |||
| Darren Waller | |||
| Questionable: | |||
| Rasul Douglas | Foot | ||
| Questionable: | |||
| Jonathan Greenard | Shoulder | ||
| Theo Jackson | Neck | ||
| Josh Metellus | Knee | ||
| Jalen Redmond | Hip | ||
| Out: | |||
| J.J. McCarthy | Concussion | ||
| On IR: | |||
| Alex Austin | |||
| Jashaun Corbin | |||
| Marcellas Dial | |||
| Antonio Gibson | |||
| Darius Harris | |||
| Lan Larison | |||
| Deneric Prince | |||
| Jaquelin Roy | |||
| Milton Williams | |||
| On IR: | |||
| Chris Board | |||
| Beaux Collins | |||
| Da'Quan Felton | |||
| Thomas Fidone II | |||
| Bryce Ford-Wheaton | |||
| Graham Gano | |||
| Micah McFadden | |||
| Darius Muasau | |||
| Malik Nabers | |||
| Cam Skattebo | |||
| Physically Unable To Perform: | |||
| Anthony Johnson Jr. | |||
| Questionable: | |||
| Jarvis Brownlee Jr. | Hip | ||
| Harrison Phillips | Foot | ||
| Out: | |||
| Xavier Gipson | Shoulder | ||
| Out: | |||
| Derrick Harmon | Knee | ||
| On IR - Designated For Return: | |||
| Rylie Mills | |||
| Questionable: | |||
| Ty Okada | Oblique | ||
| Out: | |||
| George Holani | Hamstring | ||
| On IR: | |||
| Rashad Wisdom | |||
| Questionable: | |||
| Jamel Dean | Hip | ||
| Bucky Irving | Shoulder | ||
| Baker Mayfield | Shoulder | ||
| Anthony Nelson | Ribs | ||
| Haason Reddick | Ankle | ||
| Out: | |||
| Benjamin Morrison | Hamstring | ||
| Questionable: | |||
| Elic Ayomanor | Hamstring | ||
| Chigoziem Okonkwo | Foot | ||
| Xavier Woods | Hamstring | ||
| Out: | |||
| Jalyn Armour-Davis | Achilles | ||
| Shy Tuttle | Concussion | ||
| On IR - Designated For Return: | |||
| Noah Brown | |||
| Will Harris | |||
| Drake Jackson | |||
| Out: | |||
| Jayden Daniels | Elbow | ||