Guest of the League
| Away | Home | Time | Away Probable | Home Probable | Status | |||
|---|---|---|---|---|---|---|---|---|
 | White Sox | at |  | Yankees | 1:05pm ET | Keller R (0-2) | Gil R (5-1) | |
 | Pirates | at |  | Cubs | 2:20pm ET | Falter L (2-2) | Imanaga L (5-0) | |
 | Rays | at |  | Blue Jays | 3:07pm ET | Eflin R (3-4) | Gausman R (2-3) | |
 | Rockies | at |  | Giants | 4:05pm ET | Blach L (1-2) | Harrison L (4-1) | |
 | Mariners | at |  | Orioles | 4:05pm ET | Castillo R (4-5) | Rodriguez R (4-1) | |
 | Mets | at |  | Marlins | 4:10pm ET | Severino R (2-2) | Garrett L (0-0) | |
 | Nationals | at |  | Phillies | 6:05pm ET | Gore L (2-4) | Sanchez L (2-3) | |
 | Twins | at |  | Guardians | 6:10pm ET | Ober R (4-2) | Allen L (5-2) | |
 | Athletics | at |  | Royals | 7:10pm ET | Stripling R (1-8) | Lugo R (7-1) | |
 | Brewers | at |  | Astros | 7:10pm ET | Wilson R (2-1) | Verlander R (2-2) | |
 | Red Sox | at |  | Cardinals | 7:15pm ET | Crawford R (2-2) | Mikolas R (3-5) | |
 | Angels | at |  | Rangers | 7:15pm ET | Sandoval L (2-6) | Urena R (1-3) | |
 | Tigers | at |  | Diamondbacks | 8:10pm ET | Flaherty R (1-3) | Gallen R (5-3) | |
 | Reds | at |  | Dodgers | 9:10pm ET | Ashcraft R (3-2) | Buehler R (0-1) | |
| Brewers | at | | Astros | 4:00am ET | - | - | Postponed |
 | Padres | at |  | Braves | 7:15pm ET | Darvish R (3-1) | Elder R (1-1) | Postponed |
