Guest of the League
| Away | Home | Time | Away Probable | Home Probable | Status | |||
|---|---|---|---|---|---|---|---|---|
 | Pirates | at |  | Tigers | 12:40pm ET | Jones R (3-4) | Skubal L (6-1) | 12:40pm |
 | Cardinals | at |  | Reds | 1:10pm ET | Pallante R (0-1) | Montas R (2-3) | 1:10pm |
 | Diamondbacks | at |  | Rangers | 2:35pm ET | Nelson R (3-3) | Dunning R (3-3) | 2:35pm |
 | Phillies | at |  | Giants | 3:45pm ET | Sanchez L (2-3) | Harrison L (4-1) | 3:45pm |
 | Dodgers | at |  | Mets | 4:10pm ET | Paxton L (5-0) | Peterson L (0-0) | 4:10pm |
| Pirates | at | | Tigers | 4:10pm ET | Skenes R (1-0) | Flaherty R (1-4) | 4:10pm |
 | Marlins | at |  | Padres | 4:10pm ET | Garrett L (1-0) | Darvish R (4-2) | 4:10pm |
 | Red Sox | at |  | Orioles | 6:35pm ET | Crawford R (2-3) | Burnes R (4-2) | 6:35pm |
 | Athletics | at |  | Rays | 6:50pm ET | Estes R (1-1) | Pepiot R (3-2) | 6:50pm |
 | Nationals | at |  | Braves | 7:20pm ET | Gore L (3-4) | - | 7:20pm |
 | Blue Jays | at |  | White Sox | 7:40pm ET | Manoah R (1-2) | Flexen R (2-4) | 7:40pm |
 | Royals | at |  | Twins | 7:40pm ET | Lugo R (8-1) | Ober R (5-2) | 7:40pm |
 | Cubs | at |  | Brewers | 7:40pm ET | Imanaga L (5-0) | Wilson R (3-1) | 7:40pm |
 | Guardians | at |  | Rockies | 8:40pm ET | Allen L (6-2) | Blach L (1-2) | 8:40pm |
 | Yankees | at |  | Angels | 9:38pm ET | Gil R (6-1) | Anderson L (5-4) | 9:38pm |
 | Astros | at |  | Mariners | 9:40pm ET | Verlander R (3-2) | Kirby R (4-5) | 9:40pm |
