Brett Wisely launched a two-run, walk-off home run with no outs in the ninth inning Friday night, giving the San Francisco Giants a 5-3 victory over the visiting Los Angeles Dodgers in the opener of a three-game series.

The game concluded after the Giants announced the death of franchise legend Orlando Cepeda at age 86. A moment in silence in memory of Cepeda was held before the sixth inning.

After the Dodgers tied the game on Jason Heyward's sacrifice fly in the top of the ninth off Camilo Doval (3-1), Los Angeles reliever Blake Treinen (2-2) walked Luis Matos before Wisely went deep.

Matos and Matt Chapman also homered for the Giants, who got seven innings of two-run ball from Logan Webb. San Francisco improved to 4-1 on its homestand. Andy Pages singled and tripled for the Dodgers, whose four-game winning streak ended.

Phillies 2, Marlins 0

Cristopher Sanchez threw his first career shutout to lift host Philadelphia past Miami.

Sanchez (6-3) allowed only three hits with nine strikeouts and no walks in his first complete game in his four years in the majors, all with the Phillies.

Bryson Stott drove in both of the game's runs, on a fielder's-choice grounder and a sacrifice fly. Miami starter Kyle Tyler (0-1) gave up four hits and one run in 4 2/3 innings.

Rays 3, Nationals 1

Yandy Diaz broke the Tampa Bay franchise record for longest hitting streak, Jose Siri homered twice and the Rays beat Washington in St. Petersburg, Fla.

Diaz slashed a single to center in the third inning, giving him hits in 20 straight games to break Jason Bartlett's franchise record from 2009 and move his on-base streak to a career-high 29 games.

Jacob Young was 2-for-3 with a pair of doubles, a run and a stolen base as the Nationals lost for the fourth straight time.

Yankees 16, Blue Jays 5

Juan Soto hit a three-run home run and Gleyber Torres added a two-run shot as visiting New York defeated Toronto.

Torres also had a sacrifice fly and Aaron Judge had three hits and two RBIs as the Yankees scored a season best in runs to end a four-game losing streak. Toronto's Isiah Kiner-Falefa singled and homered to extend his hit streak to 12 games and Vladimir Guerrero Jr. added a solo homer.

New York reliever Michael Tonkin (3-3) gave up one run in 1 2/3 innings. Toronto starter Yusei Kikuchi (4-8) allowed four runs in five-plus innings.

Orioles 2, Rangers 1

Albert Suarez outdueled Max Scherzer as Baltimore defeated visiting Texas.

Colton Cowser homered for the Orioles, who have captured the first two games of the four-game series and have won three in a row overall. Suarez (4-2) pitched six shutout innings, and Craig Kimbrel earned his 18th save.

Scherzer (1-1) went 5 1/3 innings, allowing two runs on four hits. The Rangers, who managed just four hits, got their run on a bases-loaded walk by Leody Taveras in the seventh inning.

Brewers 4, Cubs 2

Rookie Jackson Chourio hit his first career grand slam to pace Milwaukee past visiting Chicago for the Brewers' fifth consecutive victory.

Chourio's slam with two outs in the fourth off Jameson Taillon put the Brewers up 4-2. Milwaukee starter Colin Rea (7-2) fanned eight while allowing two runs in 5 1/3 innings, and Trevor Megill tossed a scoreless ninth for his 17th save.

Taillon (4-4) allowed four runs (three earned) on four hits in six innings for the Cubs, who have lost five of their past six. Chicago's Seiya Suzuki hit a solo homer.

Angels 5, Tigers 2

Logan O'Hoppe's tiebreaking three-run home run in the eighth inning lifted Los Angeles over Detroit in Anaheim, Calif.

The win extended the Angels' season-high winning streak to five games, while the Tigers lost their third straight. Luis Garcia (3-0) got the win in relief, and Carlos Estevez pitched a 1-2-3 ninth inning for his 16th save.

Detroit starter Kenta Maeda gave up two runs and six hits in 5 1/3 innings. Shelby Miller (4-6) gave up O'Hoppe's homer.

Mariners 3, Twins 2 (10 innings)

Cal Raleigh's chopper to the right side of the infield brought home the winning run in the 10th inning as Seattle defeated visiting Minnesota.

Mariners starter Logan Gilbert had a streak of 21 consecutive scoreless innings snapped in the sixth. He gave up two runs on four hits over six innings. Ryne Stanek (5-0) got the win over Cole Sands (2-1).

Carlos Correa, considered questionable for the game after sustaining a right wrist contusion when hit by a pitch Thursday at Arizona, homered for the Twins.

Padres 9, Red Sox 2

San Diego scored nine runs in the fifth inning and extended its winning streak to four games by beating host Boston.

The big inning featured a two-run homer from Kyle Higashioka, a three-run shot from Jackson Merrill and two-run singles from Jake Cronenworth and Donovan Solano. Boston starter Nick Pivetta (4-5) was charged with five runs on seven hits in four-plus innings.

San Diego starter Randy Vasquez exited the game after he was hit in the right forearm by a line drive to open the bottom of the fifth. Stephen Kolek (2-0) pitched two innings of scoreless relief.

Mets 7, Astros 2

Tyrone Taylor, Pete Alonso and Jeff McNeil each homered for red-hot New York, which beat Houston.

Francisco Alvarez hit a first-inning sacrifice fly and Francisco Lindor added an eighth-inning RBI double for the Mets, who improved to 16-6 this month -- the best record in the majors -- and moved over .500 at 40-39.

Jose Altuve was 2-for-5 with a leadoff homer and Yordan Alvarez reached base four times for the Astros, who, despite the loss, are an American League-best 15-8 in June.

Braves 6, Pirates 1

Charlie Morton tossed 6 1/3 shutout innings and Marcel Ozuna's three-run double highlighted a five-run third inning to lead host Atlanta over Pittsburgh.

Morton (5-4) completed the circuit of having beaten all 30 major league teams, joining Justin Verlander, Max Scherzer and Gerrit Cole as the only active pitchers to accomplish that feat.

Austin Riley homered, Ozzie Albies doubled among his two hits and Matt Olson contributed two hits and an RBI for the Braves. Pittsburgh's Bryan Reynolds singled in the eighth to extend his hitting streak to 24 games, the longest in the majors this season.

Cardinals 1, Reds 0

Andre Pallante and four relievers combined on a four-hitter as St. Louis shut out visiting Cincinnati.

Pallante (4-3) allowed four hits in 5 1/3 innings. Ryan Fernandez, JoJo Romero, Andrew Kittredge and Ryan Helsley (29th straight save) covered the last 3 2/3 innings as the Cardinals won for the sixth time in eight games.

Reds starter Frankie Montas (3-6) allowed one run on two hits in six innings. Cincinnati had its chances but couldn't break through as it lost for the third time in four games.

Royals 10, Guardians 3

Salvador Perez hit a long home run and had two RBIs as Kansas City routed visiting Cleveland.

Perez led off the second inning with a 447-foot blast to left. Hunter Renfroe sliced a homer to right for a 2-1 lead and the Royals' third set of back-to-back long balls in 2024.

Kansas City starter Alec Marsh (6-5) finished six innings, allowing a run on four hits. Guardians starter Triston McKenzie (3-5) allowed five runs on five hits in 2 2/3 innings. His 19 home runs and 49 walks allowed both lead the majors.

White Sox 5, Rockies 3

Drew Thorpe threw six solid innings, helping lead Chicago to a win over visiting Colorado.

In his fourth career start, Thorpe (2-1) allowed just two runs on two hits after rain delayed the first pitch for more than two hours. Tommy Pham finished 1-for-2 with two RBIs and two walks as Chicago won its second straight.

Brenton Doyle was 2-for-4 with two RBIs for Colorado, which lost its fourth in a row. Colorado starter Dakota Hudson (2-11) allowed five runs and six hits in five-plus innings.

Athletics 9, Diamondbacks 4

Zack Gelof went 3-for-4, including a tiebreaking triple, and scored twice and Oakland hit four homers during a victory over Arizona in Phoenix.

Shea Langeliers went 3-for-5 with a homer and two RBIs and Tyler Soderstrom hit a solo homer as Oakland snapped an 11-game road losing streak. Brent Rooker, Langeliers and Daz Cameron homered in the ninth as the A's halted a five-game skid.

Arizona's Lourdes Gurriel Jr., who had his seventh two-hit game in his past nine appearances, homered and drove in two runs. Ketel Marte had two hits and an RBI for the Diamondbacks, who lost for the fifth time in six games.