Tyler Mahle combined with four relievers on a four-hitter, Rafael Devers broke a sixth-inning tie with a three-run home run and the San Francisco Giants made it two of three from the visiting Philadelphia Phillies with a 5-0 victory Wednesday afternoon.

Making his third start as a Giant, Mahle matched zeroes with Phillies starter Aaron Nola for five innings before getting pulled after allowing a two-out single to Adolis Garcia in the sixth.

Left-hander Matt Gage (1-0) came on to strike out Brandon Marsh, preserving the scoreless tie.

That didn't last long. Willy Adames doubled with one out in the last of the sixth, and Luis Arraez followed with a walk. After Nola struck out Matt Chapman, Devers launched the first pitch he saw over the fence in center field for a 3-0 lead.

The homer was Devers' second of the season.

Caleb Kilian pitched out of a two-on, one-out jam in the seventh, Blake Tidwell threw a 1-2-3 eighth and Erik Miller worked a non-save ninth, giving the Giants a second straight win after they'd opened 1-7 at home.

Gage, the pitcher of record when the Giants scored their three runs in the sixth, was credited with the win, the first of his 55-game career. He had been 0-2.

The Giants tacked on two runs in the eighth thanks in large part to a throwing error by Jose Alvarado on an Arraez sacrifice bunt. The errant throw allowed Adames, who had singled, to score all the way from first base.

One out later, Devers made it a four-RBI day with an RBI single.

Nola (1-1) completed six innings, allowing three runs and five hits. He walked one and struck out three.

Mahle struck out six and walked four in his 5 2/3 shutout innings. He gave up three hits.

Adames and Arraez, who had a triple, joined Devers with two hits apiece for the Giants, who outscored the visitors 11-0 in the last two games of the series.

All four Phillies hits were singles, including one by Kyle Schwarber, who also walked twice in four plate appearances. Philadelphia completed a 3-3 trip.