Bryan Reynolds' two-run walk-off home run lifted the host Pittsburgh Pirates to a 6-5 win over the Minnesota Twins on Friday night.

The shot with one out in the ninth inning off Taylor Rogers (1-2) was Reynolds' second career walk-off blast.

Oneil Cruz also went deep for Pittsburgh, and Gregory Soto (4-0) pitched a scoreless top of the ninth. Pirates starter Jared Jones returned after missing 20 months due to elbow surgery, and he gave up five runs in 4 1/3 innings.

Trevor Larnach and Kody Clemens homered for the Twins, who have lost three games in a row. Taj Bradley allowed four runs over four innings.

White Sox 4, Tigers 3 (10 innings)

Miguel Vargas smacked a game-ending two-run home run against Drew Anderson in the 10th inning to propel host Chicago past Detroit.

The White Sox, who lost slugger Munetaka Murakami to hamstring tightness in the third inning, has won three straight. Stymied by Tigers starter Troy Melton, Chicago forced extra innings with aggressive baserunning in the ninth. Bryan Hudson (3-1) allowed an unearned run in the 10th on a Zack Short sacrifice fly.

The Tigers have lost three in a row and 11 of 13. Anderson (2-2) yielded the fourth walk-off home run against Detroit this season. Riley Greene singled twice for the Tigers, who were outhit 10-4.

Mets 9, Marlins 7 (10 innings)

MJ Melendez hit the first walk-off homer of his career as New York, which squandered a four-run lead, outlasted visiting Miami.

Austin Warren (1-1) threw a perfect 10th inning to strand automatic runner Jakob Marsee at third. Freddy Peralta allowed four runs (two earned) on seven hits over 4 2/3 innings. The win was the second straight for the Mets following a six-game losing streak.

Owen Caissie hit a game-tying two-run homer in the eighth for the Marlins, who have dropped three in a row. Max Meyer gave up six runs (five earned) on six hits over six innings.

Rockies 8, Giants 6

Hunter Goodman and Ezequiel Tovar homered in a five-run ninth inning, and Colorado rallied to stun San Francisco in Denver. Goodman's three-run shot off Caleb Kilian (1-3) tied the game, and three batters later, Tovar delivered a two-run, walk-off blast.

Willi Castro, Jake McCarthy, Tyler Freeman, Goodman and Tovar had two hits each and Juan Mejia (1-4) got the win for the Rockies, who snapped a five-game skid.

Jung Hoo Lee had four hits and scored twice for the Giants, who have dropped four in a row. Logan Webb made his first start since May 5 and lasted 4 1/3 innings. He allowed one run on three hits in his return from right knee bursitis.

Blue Jays 6, Orioles 5

Vladimir Guerrero Jr. hit a go-ahead two-run double in the eighth inning as Toronto wiped out a five-run deficit with late-game offense to stun host Baltimore.

Charles McAdoo homered in his major league debut and Kazuma Okamoto also went deep during the comeback by the Blue Jays, who have won eight of their past 10 games. Toronto reliever Mason Fluharty (3-0) threw 1 1/3 hitless innings. Braydon Fisher handled the ninth inning to notch his first career save, pitching around a two-out error.

Jackson Holliday, Pete Alonso and Samuel Basallo hit solo home runs for the Orioles, who have lost back-to-back games to Toronto since a three-game sweep of the American League-best Tampa Bay Rays.

Cardinals 6, Cubs 5

Ivan Herrera belted a go-ahead solo homer in the fifth inning, and host St. Louis topped Chicago to end a four-game losing streak.

Nelson Velazquez hit a three-run homer in his Cardinals debut, and Thomas Saggese also went deep. St. Louis used seven pitchers, with reliever Gordon Graceffo (4-1) getting the win and Riley O'Brien logging his 14th save.

The Cubs' Ian Happ went deep for the third straight game, belting a three-run homer in the first inning. Shota Imanaga (4-6) surrendered three homers and five runs in 5 1/3 innings.

Brewers 5, Astros 4 (10 innings)

Brice Turang produced a sacrifice fly that scored Christian Yelich in the top of the 10th inning, and visiting Milwaukee rallied past Houston.

Brewers reliever Abner Uribe (3-2) retired Brice Matthews and Isaac Paredes with the bases loaded in the bottom of the ninth. Trevor Megill earned his seventh save with a scoreless 10th after Milwaukee got the go-ahead run against Astros reliever Alimber Santa (0-1).

David Hamilton and Jackson Chourio homered for Milwaukee, which erased a 4-1 deficit to earn its fourth consecutive win. Cam Smith went deep for Houston, which had won six of its previous seven games.

Dodgers 4, Phillies 2

Justin Wrobleski gave up one run on one hit over seven innings as Los Angeles increased its winning streak to six games with a victory over visiting Philadelphia.

Wrobleski (7-2) recorded a career-high nine strikeouts with no walks on 88 pitches. Freddie Freeman hit a first-inning home run and Max Muncy, Shohei Ohtani and Will Smith also went deep as the Dodgers won for the 13th time in their past 15 games.

Kyle Schwarber homered, but Zack Wheeler gave up four home runs as the Phillies saw their three-game winning streak come to an end. Wheeler (4-1) permitted four runs on five hits over six innings.

Rangers 9, Royals 1

MacKenzie Gore (4-4) allowed four hits over 6 1/3 scoreless innings and Ezequel Duran's two-run single highlighted a four-run first as Texas topped Kansas City in Arlington, Texas.

Brandon Nimmo and Nicky Lopez each clubbed a two-run homer and Joc Pederson hit a solo shot for the Rangers, who had lost six of their previous seven.

Vinnie Pasquantino had two hits and an RBI for the Royals, who took their fourth loss in a row. Stephen Kolek (3-1) yielded six runs, four earned, in five innings.

Padres 7, Nationals 5

Jackson Merrill cracked a tiebreaking two-run homer in the seventh and Fernando Tatis Jr. had three hits as visiting San Diego rallied for a win against Washington.

Ty France added a game-tying solo homer in the sixth for the Padres, who snapped a four-game losing streak. Jeremiah Estrada (2-1) pitched 1 1/3 scoreless innings to set the table for Mason Miller, who got four outs for his 17th save. Merrill and France drilled their home runs off reliever Mitchell Parker (2-2), who allowed three runs (one earned).

Curtis Mead and Keibert Ruiz homered for Washington, which opened a six-game homestand by falling to 10-17 at Nationals Park.

Yankees 8, Athletics 2

Paul Goldschmidt hit a three-run homer and Ryan McMahon and Ben Rice added solo blasts as New York rolled to an easy victory over the Athletics in West Sacramento, Calif.

Rice had a season-high four hits and two RBIs and Aaron Judge also drove in two runs as the Yankees stretched their winning streak to five games. Carlos Rodon (1-2) gave up one run and four hits over six innings.

Nick Kurtz homered for the Athletics, who have been outscored 30-6 while losing four consecutive games. Rookie Henry Bolte had a career-best three hits. Athletics starter Luis Severino (2-6) gave up four unearned runs in the first inning before exiting due to right arm soreness.

Mariners 7, Diamondbacks 6 (10 innings)

Randy Arozarena doubled home the winning run with one out in the bottom of the 10th inning as Seattle edged visiting Arizona.

J.P. Crawford homered twice and Julio Rodriguez and Luke Raley also went deep as the Mariners won their fourth game in a row. Rodriguez went 3-for-5.

Geraldo Perdomo belted a solo shot for the Diamondbacks, who had a five-game winning streak snapped. Perdomo and Gabriel Moreno each had three hits.

Rays 8, Angels 5

Nick Martinez tossed seven quality innings and Tampa Bay rallied with seven runs in the seventh inning to stop a season-high four-game losing streak in a win over Los Angeles in St. Petersburg, Fla.

Martinez (5-1) extended his streak of allowing two runs or fewer to 11 consecutive starts to open 2026, yielding two on eight hits over seven innings. Yandy Diaz homered twice, and Jonathan Aranda went deep.

The Angels' Vaughn Grissom (two RBIs, run) and Zach Neto (two runs, RBI, walk) and Jose Siri each had a double and a single. In his first major league game in two years, Nick Madrigal went 2-for-4.

Braves 8, Reds 3

Michael Harris II went 3-for-5 with three RBIs, Ronald Acuna Jr. homered and visiting Atlanta posted a victory over Cincinnati.

Jorge Mateo drove in two runs and Dominic Smith had three hits and two runs for the Braves, who improved to 20 games above .500. Grant Holmes tossed 4 2/3 innings, allowing three runs on seven hits. Didier Fuentes (4-0) threw 1 1/3 scoreless innings.

Chris Paddack (0-7) gave up four runs on seven hits across five innings for the Reds, who dropped their second straight after winning five of their previous six. JJ Bleday and Nathaniel Lowe homered for Cincinnati.

Guardians 4, Red Sox 3

A four-run first inning carried Cleveland to a victory over visiting Boston.

The decisive rally included RBI singles by Rhys Hoskins and Angel Martinez, a Ceddanne Rafaela error that allowed a run to score, and a Patrick Bailey sacrifice fly. All four runs were charged to Red Sox opener Tyler Samaniego (0-3).

Guardians reliever Colin Holderman (3-0) pitched 1 1/3 scoreless innings, and Cade Smith struck out three in the ninth to collect his 20th save. Boston's Brayan Bello pitched seven scoreless innings.