Dodgers two-way star Shohei Ohtani exited Los Angeles' Thursday game at Pittsburgh in the top of the seventh inning because of left knee inflammation.

Ohtani was 2-for-2 with his second home run in as many games and had reached base four times before his departure. Santiago Espinal replaced him as the Dodgers' designated hitter.

Earlier in the game, the Dodgers also lost starting pitcher Justin Wrobleski, who took a 96.2 mph comebacker off his upper leg and then collided with Bryan Reynolds on the latter's infield single in the fifth inning.

The left-hander came out due to a right hamstring contusion. He allowed four runs on six hits (two home runs) in 4 2/3 innings.

Ohtani opened the scoring in the third inning by depositing a 3-2 sweeper from Mitch Keller over the wall in right-center field for a solo shot. The long ball was the 13th of the season for Ohtani, who launched a two-run blast in the Dodgers' 9-8 loss to the Pirates on Wednesday.