Ketel Marte smacked a two-run homer, Ildemaro Vargas also drove two runs and the visiting Arizona Diamondbacks made it five straight wins over the San Francisco Giants with a 7-5 victory on Tuesday.

Adrian Del Castillo chipped in with a homer and Eduardo Rodriguez (5-1) threw six effective innings for the Diamondbacks, who swept a three-game home series from the Giants last week and have now won the last two days in San Francisco.

Casey Schmitt, Eric Haase and Willy Adames homered for the Giants, who lost for the sixth time in their past eight games.

After the homer by Del Castillo and a pair of run-scoring infield outs from Vargas helped Arizona build a 4-2 lead, Marte produced the game's biggest hit. He belted a two-run shot, his ninth homer of the year, off Erik Miller in the seventh inning.

Gabriel Moreno added an RBI single in the eighth to give the Arizona bullpen a 7-3 cushion before Rafael Devers' run-scoring double got the Giants within three in the last of the eighth.

A two-out solo homer by Willy Adames, his seventh, narrowed the gap to 7-5 in the ninth before Paul Seward struck out Schmitt to shut the door and notch his 13th save.

Rodriguez was pulled with a 6-2 lead. He allowed two runs and six hits in six innings, with two walks and six strikeouts.

Giants starter Tyler Mahle (1-7) worked five innings, limiting the Diamondbacks to three runs and three hits. He walked three and struck out three.

Del Castillo socked his fourth homer of the season for the Diamondbacks, who got hits from eight different players, runs from seven and RBIs from four.

Schmitt produced his 12th homer while Haase belted his third. They joined Adames with two hits apiece for the Giants, who out-hit the visitors 9-8.