Arizona Cardinals quarterback Jacoby Brissett completed 47 of his 57 pass attempts for 452 passing yards, two touchdowns, and two interceptions during Sunday's Week 11 loss against the San Francisco 49ers. Brissett's 47 completions broke the NFL's all-time single-game record, surpassing Jared Goff and Drew Bledsoe, who both once had 45 completions. The two turnovers are a blemish on his stat line, but the veteran quarterback still drastically exceeded expectations in fantasy football, even without Marvin Harrison Jr. (appendix) at his disposal. He has 11 total touchdowns in five games since taking over for Kyler Murray (foot), and during that span, he ranks as the overall QB4 in fantasy points per game. He has emerged as a must-start quarterback for Week 12 against the Jacksonville Jaguars.

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Arizona Cardinals tight end Trey McBride caught 10 of his 11 targets for 115 yards and one touchdown during Sunday's Week 11 loss against the San Francisco 49ers. McBride was already the top weapon in Arizona's passing attack, but he took on an even larger role this week with Marvin Harrison Jr. (appendix) sidelined. The tight end benefited from Jacoby Brissett completing 47 passes, which is a new NFL all-time single-game record. McBride now has five consecutive games with a touchdown, scoring six different times in that span. He'll remain a must-start, high-end TE1 even after Harrison returns to action. The Cardinals will host the Jacksonville Jaguars in Week 12.

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San Francisco 49ers running back Christian McCaffrey had 13 carries for 81 rushing yards and two rushing touchdowns during Sunday's Week 11 win over the Arizona Cardinals. He also caught five of his six targets for an additional 40 receiving yards and one receiving touchdown. The superstar running back continues to demonstrate excellence as a rusher and receiver, and his big game officially propelled him past Jonathan Taylor for the overall RB1 spot (PPR) through 11 weeks. Given that he was a late-first-round pick in most redraft leagues this year, managers are getting even more than they expected from the 29-year-old. He remains a must-start RB1 for Week 12 against his old team, the Carolina Panthers.

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Arizona Cardinals wide receiver Michael Wilson caught 15 of his 18 targets for 185 yards during Sunday's Week 11 loss to the San Francisco 49ers. We knew Wilson was going to take on an expanded role with Marvin Harrison Jr. (appendix) sidelined, but nobody could have predicted that he would be this involved and productive against the Niners. He benefited from Jacoby Brissett setting a new record for most completions (47) in a single game in NFL history. It's unlikely that Brissett throws the ball as much next week, and it's also too early to tell whether Harrison will miss additional time. Nevertheless, Wilson's big game will keep him in the WR3/flex tier with WR2 upside for Week 12 against the Jacksonville Jaguars.

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Detroit Lions wide receiver Isaac TeSlaa (oblique) is officially active for Week 11 against the Philadelphia Eagles on Sunday Night Football. He was listed as questionable after being a late addition to the injury report. The rookie has occupied a depth role in his first pro season, catching four of seven targets for 65 yards and two touchdowns through nine games. He remains off the redraft radar as long as Amon-Ra St. Brown and Jameson Williams are both healthy.

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Houston Texans WR Christian Kirk ended up with a single 6-yard reception on four targets in Week 11 against the Tennessee Titans.

Fantasy Spin: Kirk had three or more receptions in his first four games this season, but he has tailed off working with backup QB Davis Mills, who has subbed for the injured QB C.J. Stroud (concussion) in the past two contests. Kirk's fantasy appeal remains limited to deeper leagues, especially as long as Mills is under center.

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Houston Texans RB Nick Chubb rushed three times for 17 yards in Week 11 against the Tennessee Titans, and he did not have a reception on two targets.

Fantasy Spin: The veteran had his shot at the workhorse job, but he has been surpassed by rookie Woody Marks, who has been much more productive. Chubb is only worth a roster spot in deeper fantasy leagues at this juncture.

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Houston Texans DE Danielle Hunter went for four total stops, a solo tackle, 1.5 sacks, a tackle for loss and a game-high three quarterback hits in Week 11 against the Tennessee Titans.

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Atlanta Falcons quarterback Michael Penix Jr. (knee) aggravated the same knee injury that forced him to miss time earlier this season, according to Ian Rapoport of NFL Network. The second-year quarterback had completed 13 of his 16 pass attempts for 175 yards before exiting Sunday's Week 11 loss against the Carolina Panthers. Rapoport notes that Penix is headed for additional testing, but the initial expectation is that he will miss time. That would leave Kirk Cousins in line to make his second start of the season next Sunday against the New Orleans Saints. The veteran went just 6-for-14 passing with 48 yards in relief of Penix this week. He led zero touchdown drives but did get Atlanta in position for two fourth-quarter field goals.

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Houston Texans TE Dalton Schultz ended up with six catches for 51 yards on nine targets in Week 11 against the Tennessee Titans.

Fantasy Spin: Schultz has picked up the pace with six or more receptions in each of the past three games, and he has 51 or more receiving yards in three in a row, and five of the past six outings. He has re-emerged as a low-end TE1 in PPR leagues, with slightly lesser appeal in standard play.

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Cleveland Browns quarterback Dillon Gabriel (concussion) has entered the league's concussion protocol, leaving his status for Week 12 against the Las Vegas Raiders up in the air. However, according to head coach Kevin Stefanski, Gabriel will remain the starter if he is healthy and clears concussion protocol. The Oregon product was replaced by fellow rookie Shedeur Sanders following his injury, but it didn't go very well as Sanders completed just four of his 16 pass attempts, took two sacks, and threw an interception. Gabriel, on the other hand, went 7-for-10 passing with 68 yards through the air, and he also led four scoring drives. Cleveland is at its best when it controls the rushing attack, which leaves Gabriel outside the top 24 fantasy quarterbacks going forward.

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Cleveland Browns quarterback Shedeur Sanders will return to the backup role if Dillon Gabriel (concussion) clears concussion protocol ahead of Week 12 against the Las Vegas Raiders. Head coach Kevin Stefanski confirmed that Gabriel will be the starter when healthy. Gabriel exited midway through Sunday's Week 11 contest against the Baltimore Ravens. He had orchestrated a six-point lead, but Sanders struggled upon entering, completing just four of his 16 pass attempts with one interception and two sacks. Neither Gabriel nor Sanders is very appealing in redraft leagues, and both would rank outside the top 24 quarterbacks against Las Vegas.

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Buffalo Bills wide receiver Tyrell Shavers caught four of his five targets for a team-high 90 yards and a touchdown during Sunday's Week 11 win over the Tampa Bay Buccaneers. His biggest play of the game was a 43-yard touchdown that temporarily gave Buffalo the lead in the second quarter. Shavers capitalized on an increased opportunity to produce with Keon Coleman (coach's decision) inactive. The third-year receiver played 53.6% of the offensive snaps, setting a new career-high. Coleman should return to action next week, but Shavers has shown that he deserves to compete for more opportunities alongside Coleman, Khalil Shakir, and Joshua Palmer.

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Jacksonville Jaguars running back Travis Etienne Jr. had 19 carries, 73 rushing yards, and two rushing touchdowns during Sunday's Week 11 win over the Los Angeles Chargers. He was unable to haul in either of his two targets in the passing game. Etienne ceded early-game touches to Bhayshul Tuten (ankle), but then the rookie left the game with an injury, clearing the way for Etienne to re-establish himself as the lead back. The 26-year-old took full advantage of the opportunity, helping fuel a 35-6 upset victory at home. If Tuten is healthy in Week 12, we could see somewhat of a 50/50 backfield split, as both running backs have proven that they are effective and can provide a spark. In a split backfield, Etienne is a low-end RB2. However, he would jump to the RB1 tier if he operates as the workhorse or if Tuten misses time.

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Updating a previous report, Pittsburgh Steelers QB Aaron Rodgers (wrist) left the Week 11 game against the Cincinnati Bengals due to a left wrist injury, head coach Mike Tomlin said Sunday, Nov. 16. Rodgers will be further evaluated Monday. QB Mason Rudolph came on and finished up the home victory.

Fantasy Spin: Rodgers did a decent job before departing, completing 9-of-15 passes for 116 yards and one touchdown in the first half. When healthy, Rodgers is a QB2 in most fantasy leagues at this point of his career.

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Tennessee Titans WR Calvin Ridley (leg) suffered a broken fibula during the Week 11 game and will miss the rest of the season, according to interim head coach Mike McCoy.

Fantasy Spin: Van Jefferson, Mason Kinsey and Elic Ayomanor are all candidates for more targets with Ridley unavailable. Ayomanor may have the most value among the three, but none of them are strong fantasy options.

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The Detroit Lions have declared CB Terrion Arnold, WR Tom Kennedy, DT Mekhi Wingo, S Kerby Joseph, DL Quinton Jefferson and RB Craig Reynolds inactive for Week 11.

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Houston Texans wide receiver Nico Collins caught nine of his 10 targets for 92 yards and a touchdown during Sunday's Week 11 win over the Tennessee Titans. Collins paced the team in all major receiving categories, building on an equally impressive performance from back in Week 10. The Texans' top receiver has strung together three impressive games in a row, amassing at least 10 targets, seven receptions, and 14.5 fantasy points (PPR) in each of those contests. He ranks as a top-24 fantasy receiver this season, but his latest hot streak has him teetering on the edge of the WR1 tier for a Week 12 contest against the Buffalo Bills that will likely require C.J. Stroud (concussion) to throw a lot.

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Pittsburgh Steelers TE Jonnu Smith was targeted two times during the Week 11 game against the Cincinnati Bengals but finished the game with zero receptions.

Fantasy Spin: Smith was a valuable fantasy tight end last season but has been held to under 30 yards in every game this season. He can be avoided in all fantasy leagues.

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San Francisco 49ers kicker Eddy Pineiro (hamstring) is considered questionable to return to Sunday's game against the Arizona Cardinals. Pineiro appears to have pulled his hamstring during the second half of this contest. The assumption is that punter Thomas Morstead would take over as the kicker for the rest of the contest. The 49ers are already up multiple scores in the middle of the fourth quarter. That being said, San Francisco might elect to not kick at all. Before exiting, Pineiro knocked down all three field goal attempts, while connecting on 2-of-4 extra points kicks in this game. Fantasy managers will need to check back for another update on Pineiro.

From RotoBaller