Tennessee Titans running back Tyjae Spears (ankle) exited during the third quarter of Sunday's game against the New York Jets. He was observed walking to the locker room with one shoe removed. At the time of his departure, he had 20 rushing yards, 11 receiving yards, and 22 kick return yards. Tennessee has Tony Pollard atop its depth chart, so he'll continue to handle the bulk of the rushing workload regardless of whether Spears can return. Julius Chestnut would be next on the depth chart.

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New England Patriots linebackers Ja'Whaun Bentley (shoulder) and Oshane Ximines (knee) have been downgraded to out for the remainder of Week 2 versus the Seattle Seahawks. Both are impact players in New England's defense. However, neither player had registered a tackle at the time of their respective departures. Joshua Uche and Raekwon McMillan figure to earn more opportunities with two key linebackers sidelined.

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Pittsburgh Steelers quarterback Russell Wilson (calf) is officially inactive for Week 2, as expected. He has been designated as the Steelers' emergency third quarterback, which means he could enter the game if both Justin Fields and Kyle Allen suffer injuries and can't return. Fields is on track to make his second consecutive start, and if Pittsburgh starts 2-0, they could continue to ride the hot hand regardless of whether Wilson is healthy in Week 3.

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Minnesota Vikings wide receiver Justin Jefferson (quad) exited during the fourth quarter of Sunday's game against the San Francisco 49ers and is officially questionable to return. He had been quite productive prior to his departure, catching four passes for 133 yards and one touchdown. Jordan Addison (ankle) was inactive this week, so Minnesota's top receivers will be Jalen Nailor and Trent Sherfield until Jefferson can return. In the event that both Jefferson and Addison can't suit up next week, Nailor would be a solid WR3 option for fantasy purposes.

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Pittsburgh Steelers wide receiver Roman Wilson (ankle) is inactive for Week 2 against the Denver Broncos. Wilson had been listed as questionable after logging a limited practice on Friday. The rookie didn't up last week either, so he's still looking to make his NFL debut. With Wilson sidelined, Scotty Miller and Ben Skowronek should earn more opportunities behind George Pickens, Van Jefferson, and Calvin Austin III.

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Cleveland Browns wide receiver David Bell (hip) won't return to Sunday's matchup with the Jacksonville Jaguars. The wideout had three catches for 27 yards. Unfortunately, he suffered a hip injury on his last catch of the day. With David Njoku (ankle) ruled out ahead of Week 2 and Pierre Strong Jr. (hamstring) exiting Sunday's contest, the Browns continue to deal with injuries on the offensive side of the ball. Fantasy managers should expect more work for Elijah Moore, Jerry Jeudy, Jerome Ford, and D'Onta Foreman for the rest of the game.

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Cleveland Browns running back Pierre Strong Jr. (hamstring) exited during the second half of Sunday's game against the Jacksonville Jaguars and will not return. At the time of his departure, he had 10 rushing yards, 25 kick return yards, and -5 receiving yards. Despite some speculation that Strong may operate as the Browns' primary backup running back this week, he was ultimately out-produced by both Jerome Ford and D'Onta Foreman before he exited the contest. Strong will remain off the fantasy radar even if he's healthy enough to play in Week 3.

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Cincinnati Bengals wide receiver Tee Higgins (hamstring) is officially inactive for Sunday's AFC showdown with the Chiefs. There is no surprise here, considering the wideout missed Week 1 and was doubtful heading into Week 2. Fortunately, Joe Burrow has Ja'Marr Chase as his primary pass-catcher. There's also room for Andrei Iosivas, Trenton Irwin, and Mike Gesicki to enter the flex conversation in 12-team fantasy leagues and up.

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According to NFL insider Jay Glazer, Chicago Bears wide receiver Keenan Allen (heel) is on the "doubtful side" for Sunday's game against the Texans. The veteran wideout was classified as a game-time decision. However, it appears the Bears will be without Allen, who caught just 4 of 11 targets for 29 yards in Week 1. With Rome Odunze (knee) also in danger of missing the Week 2 festivities, DJ Moore and Cole Kmet could see more attention from Caleb Williams. There's also potential for Velus Jones Jr. and DeAndre Carter to get more involved. Yet, Jones or Carter shouldn't be viewed as anything more than a desperation addition to any fantasy lineup.

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Jacksonville Jaguars running back Tank Bigsby (shoulder) is questionable to return to Sunday's matchup with the Cleveland Browns. The 23-year-old took a hard shot while returning a kick, with many assuming he suffered a concussion. However, it appears a shoulder injury is jeopardizing his availability for the remainder of Week 2. Bigsby had 12 carries for 73 yards in Week 1 versus the Dolphins. Yet, he has been quiet on Sunday. At any rate, fantasy managers could see D'Ernest Johnson backing up Travis Etienne Jr. for the remainder of the contest.

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Tampa Bay Buccaneers running back Rachaad White (groin) returned to Sunday's meeting with the Detroit Lions. He exited the contest briefly due to a groin issue and was listed as questionable to return. However, while it's good to see White back on the field, fantasy managers shouldn't be surprised to see him receive a reduced workload, with Bucky Irving potentially in line to see more work for the remainder of Week 2. There's also a good chance White appears on the injury report ahead of Tampa's Week 3 clash with the Denver Broncos, meaning fantasy managers should plan in advance.

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New York Jets linebacker C.J. Mosley (foot) is questionable to return to Sunday's game against the Titans. The veteran suffered a foot injury. But his day is likely over, considering he was transported to the locker room on a cart. He finished last season by totaling 151 tackles, one of the highest marks of his career. Unfortunately, the situation doesn't look promising regarding Mosley's availability moving ahead. Nonetheless, IDP managers will likely get an update soon.

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New York Giants wide receiver Malik Nabers (head) cleared concussion protocol and returned to Sunday's NFC East battle with the Commanders. The rookie wideout took a shot to the head, resulting in a trip to the blue medical tent for an evaluation. Fortunately, fantasy managers can breathe a sigh of relief. He popped up on the injury report earlier in the week due to a knee injury. However, he was cleared to suit up after practicing in full on Friday. Without question, the Giants can't afford an injury, considering kicker Graham Gano (groin) left the contest with a groin injury.

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Tampa Bay Buccaneers running back Rachaad White (groin) is questionable to return to Sunday's matchup with the Detroit Lions. It's a tough blow for fantasy managers, considering the injury came early in the contest. He'll finish the game with three carries for 12 yards if he can't return. At any rate, there should be an update on White's condition soon. In the meantime, Bucky Irving should handle most of the snaps out of the backfield.

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New York Giants kicker Graham Gano (groin) is doubtful to return to Sunday's matchup with the Washington Commanders. The veteran popped up on Saturday's edition of the injury report because of a groin injury. However, he didn't have a game status, so most assumed he was healthy enough to suit up. While that was true at the time, it now appears the issue could keep him out for the remainder of Week 2. Fantasy managers also shouldn't be surprised to see Gano miss time, although it's too early to speculate. The Giants don't have an emergency replacement, meaning New York may need to be more aggressive than usual on the offensive end for the rest of the contest.

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Detroit Lions defensive end Marcus Davenport (groin) is officially inactive for Week 2 against the Tampa Bay Buccaneers. He was trending in the wrong direction after being listed as doubtful. The 28-year-old is coming off his debut with the team in which he registered half a sack. Look for James Houston and Josh Paschal to earn more opportunities in his absence.

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San Francisco 49ers safety Talanoa Hufanga (knee) is inactive for Week 2 versus the Minnesota Vikings. He had been listed as doubtful. Hufanga tore his ACL last season and has not yet appeared in a game in 2024. The 25-year-old had seven interceptions, two forced fumbles, and two sacks through 27 games between 2022 and 2023. George Odum will start in his place this week.

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Washington Commanders wide receiver Jamison Crowder (coach's decision) is a healthy scratch for Week 2 against the New York Giants. The veteran had logged just three snaps in the season opener, catching one pass for five yards. Fellow receiver Noah Brown will be active in Crowder's place. Brown had been a healthy scratch in Week 1 as he was still acclimating to the Commanders' offense. Even if this dynamic remains in place for weeks to come (Brown active, Crowder inactive), Brown isn't a reliable fantasy option.

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New Orleans Saints cornerback Marshon Lattimore (hamstring) is officially inactive for Week 2 versus the Dallas Cowboys. He had been listed as questionable but was trending in the wrong direction after not practicing on Friday. By Sunday morning, reports emerged indicating that the Saints wanted to be cautious with Lattimore and might hold him out. Indeed, he'll sit out. Lattimore had been slated to cover CeeDee Lamb on Sunday, so this development is great news for the Cowboys' WR1 and fantasy managers who have him on their rosters.

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New Orleans Saints wide receiver A.T. Perry (coach's decision) is a healthy scratch for Week 2 against the Dallas Cowboys. The 24-year-old missed Week 1 with a hand injury but was a full participant in practice this week. Now, he's sidelined again, but this time for non-injury reasons. The Saints will enter their second game of the season with Chris Olave and Rashid Shaheed atop their depth chart, followed by undrafted rookie Mason Tipton as their No. 3 receiver.

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