

| On IR: | |||
| Trishton Jackson | |||
| Justin Jones | |||
| J.J. Russell | |||
| Physically Unable To Perform: | |||
| Bilal Nichols | |||
| BJ Ojulari | |||
| Questionable: | |||
| Owen Pappoe | Quadricep | ||
| Dante Stills | Heel | ||
| On IR - Designated For Return: | |||
| Ta'Quon Graham | |||
| Physically Unable To Perform: | |||
| Troy Andersen | |||
| Questionable: | |||
| Darnell Mooney | Shoulder | ||
| Out: | |||
| DeMarcco Hellams | Hamstring | ||
| On IR: | |||
| Bilhal Kone | |||
| Robert Longerbeam | |||
| On IR - Designated For Return: | |||
| Adisa Isaac | |||
| Physically Unable To Perform: | |||
| Ar'Darius Washington | |||
| Out: | |||
| Isaiah Likely | Foot | ||
| Patrick Ricard | Calf | ||
| On IR: | |||
| Tyler Bass | |||
| DeWayne Carter | |||
| Gabriel Davis | |||
| Maxwell Hairston | |||
| Suspended: | |||
| Michael Hoecht | |||
| Larry Ogunjobi | |||
| Doubtful: | |||
| Tre'Davious White | Groin | ||
| On IR: | |||
| Jalen Coker | |||
| On IR - Designated For Return: | |||
| LaBryan Ray | |||
| Physically Unable To Perform: | |||
| Jonathon Brooks | |||
| Out: | |||
| Damarri Mathis | Knee | ||
| On IR: | |||
| Austin Booker | |||
| Deion Hankins | |||
| Terell Smith | |||
| On IR - Designated For Return: | |||
| Travis Homer | |||
| Amen Ogbongbemiga | |||
| Questionable: | |||
| Jaylon Johnson | Leg | ||
| Out: | |||
| Ian Wheeler | Undisclosed | ||
| On IR - Designated For Return: | |||
| Daijahn Anthony | |||
| Cedric Johnson | |||
| Physically Unable To Perform: | |||
| Erick All | |||
| On IR: | |||
| Martin Emerson | |||
| Nathaniel Watson | |||
| On IR - Designated For Return: | |||
| Winston Reid | |||
| Physically Unable To Perform: | |||
| Jeremiah Owusu-Koramoah | |||
| Deshaun Watson | |||
| Out: | |||
| Michael Hall Jr. | Knee | ||
| On IR: | |||
| Caelen Carson | |||
| Phil Mafah | |||
| John Stephens Jr. | |||
| On IR - Designated For Return: | |||
| Jonathan Mingo | |||
| Payton Turner | |||
| Physically Unable To Perform: | |||
| Josh Butler | |||
| DeMarvion Overshown | |||
| Out: | |||
| Perrion Winfrey | Back | ||
| On IR: | |||
| Michael Burton | |||
| Matt Henningsen | |||
| On IR - Designated For Return: | |||
| Drew Sanders | |||
| Out: | |||
| Nate Adkins | Ankle | ||
| Dre Greenlaw | Quad | ||
| On IR: | |||
| Dan Jackson | |||
| Ennis Rakestraw Jr. | |||
| Ezekiel Turner | |||
| Kenny Yeboah | |||
| Physically Unable To Perform: | |||
| Alim McNeill | |||
| Levi Onwuzurike | |||
| Malcolm Rodriguez | |||
| Out: | |||
| Sione Vaki | Hamstring | ||
| On IR - Designated For Return: | |||
| MarShawn Lloyd | |||
| Physically Unable To Perform: | |||
| Collin Oliver | |||
| Christian Watson | |||
| Questionable: | |||
| Zayne Anderson | Knee | ||
| Nate Hobbs | Knee | ||
| Micah Parsons | Back | ||
| Jayden Reed | Foot | ||
| Barryn Sorrell | Knee | ||
| Dontayvion Wicks | Calf | ||
| Savion Williams | Hamstring | ||
| On IR: | |||
| Kyonte Hamilton | |||
| Brevin Jordan | |||
| Irv Smith Jr. | |||
| On IR - Designated For Return: | |||
| Jaylen Reed | |||
| Physically Unable To Perform: | |||
| Denico Autry | |||
| Tank Dell | |||
| Out: | |||
| Braxton Berrios | Hamstring | ||
| Christian Kirk | Hamstring | ||
| On IR: | |||
| Salvon Ahmed | |||
| D.J. Montgomery | |||
| Jacob Phillips | |||
| Justin Walley | |||
| Hunter Wohler | |||
| On IR - Designated For Return: | |||
| Jaylon Carlies | |||
| Questionable: | |||
| Tyler Goodson | Elbow | ||
| On IR: | |||
| Joshua Cephus | |||
| Caleb Ransaw | |||
| On IR - Designated For Return: | |||
| Jalen McLeod | |||
| Out: | |||
| Montaric Brown | Ankle | ||
| On IR: | |||
| Felix Anudike-Uzomah | |||
| Jake Briningstool | |||
| Deon Bush | |||
| Keaontay Ingram | |||
| Nazeeh Johnson | |||
| Janarius Robinson | |||
| Eric Scott Jr. | |||
| Suspended: | |||
| Rashee Rice | |||
| Questionable: | |||
| Omarr Norman-Lott | Ankle | ||
| Out: | |||
| Jalen Royals | Knee | ||
| On IR: | |||
| Junior Colson | |||
| Jalen Reagor | |||
| On IR - Designated For Return: | |||
| Deane Leonard | |||
| Questionable: | |||
| Ahkello Witherspoon | Knee | ||
| On IR: | |||
| Aidan O'Connell | |||
| On IR - Designated For Return: | |||
| Lonnie Johnson | |||
| On IR: | |||
| Artie Burns | |||
| Jalin Conyers | |||
| Kader Kohou | |||
| Alexander Mattison | |||
| On IR - Designated For Return: | |||
| Jason Sanders | |||
| Questionable: | |||
| D'Wayne Eskridge | Concussion | ||
| Out: | |||
| Darren Waller | Hip | ||
| Jaylen Wright | Knee | ||
| On IR: | |||
| Rondale Moore | |||
| Suspended: | |||
| Jordan Addison | |||
| On IR - Designated For Return: | |||
| C.J. Ham | |||
| Physically Unable To Perform: | |||
| Gavin Bartholomew | |||
| On IR: | |||
| Marcellas Dial | |||
| Lan Larison | |||
| Ja'Lynn Polk | |||
| Deneric Prince | |||
| Jaquelin Roy | |||
| Jahlani Tavai | |||
| Out: | |||
| Christian Gonzalez | Hamstring | ||
| On IR: | |||
| Bub Means | |||
| On IR - Designated For Return: | |||
| John Ridgeway | |||
| Physically Unable To Perform: | |||
| Taysom Hill | |||
| Foster Moreau | |||
| Questionable: | |||
| Jordan Howden | Oblique | ||
| Out: | |||
| Chase Young | Calf | ||
| On IR: | |||
| Bryce Ford-Wheaton | |||
| Physically Unable To Perform: | |||
| Victor Dimukeje | |||
| Eric Gray | |||
| Anthony Johnson Jr. | |||
| On IR: | |||
| Kris Boyd | |||
| Byron Cowart | |||
| Physically Unable To Perform: | |||
| Irvin Charles | |||
| On IR: | |||
| Johnny Wilson | |||
| Physically Unable To Perform: | |||
| Nakobe Dean | |||
| Out: | |||
| Tanner McKee | Right Thumb | ||
| On IR: | |||
| Will Howard | |||
| Donte Kent | |||
| Dean Lowry | |||
| Donald Parham | |||
| On IR - Designated For Return: | |||
| Cory Trice Jr. | |||
| Questionable: | |||
| Nick Herbig | Hamstring | ||
| Skylar Thompson | Hamstring | ||
| Out: | |||
| Derrick Harmon | Knee | ||
| On IR: | |||
| Kenny McIntosh | |||
| Out: | |||
| Jake Bobo | Concussion | ||
| Uchenna Nwosu | Knee | ||
| Dareke Young | Hamstring | ||
| On IR: | |||
| Jacob Cowing | |||
| Tre'Vius Hodges-Tomlinson | |||
| Tarron Jackson | |||
| Corey Kiner | |||
| Trent Taylor | |||
| Patrick Taylor | |||
| Suspended: | |||
| Demarcus Robinson | |||
| On IR - Designated For Return: | |||
| Kevin Givens | |||
| Physically Unable To Perform: | |||
| Brandon Aiyuk | |||
| Malik Mustapha | |||
| Questionable: | |||
| Christian McCaffrey | Calf | ||
| Doubtful: | |||
| Jordan James | Finger | ||
| Jordan Watkins | Ankle | ||
| On IR: | |||
| Jalen McMillan | |||
| David Walker | |||
| Questionable: | |||
| Vita Vea | Foot | ||
| Out: | |||
| Chris Godwin | Ankle | ||
| Christian Izien | Oblique | ||
| Benjamin Morrison | Quad | ||
| On IR: | |||
| Treylon Burks | |||
| Will Levis | |||
| Anfernee Orji | |||
| On IR - Designated For Return: | |||
| Tyjae Spears | |||
| Questionable: | |||
| Kalel Mullings | Ankle | ||
| L'Jarius Sneed | Knee | ||
| Doubtful: | |||
| Kevin Winston Jr. | Hamstring | ||
| On IR: | |||
| Tyree Jackson | |||