Tampa Bay Buccaneers running back Bucky Irving is trending towards making his first career start during Sunday's game against the New Orleans Saints. Fellow back Rachaad White (foot) has been limited to one practice this week and is considered a game-time decision for Week 6. If White sits, Irving is expected to get a majority of the snaps in the backfield. He has been effective this season with 247 yards on 44 carries, which is 5.6 yards per carry. The Saints defense is middle of the road when it comes to defending against the run. Irving should be to find success and is in the RB2 conversation, assuming White is unable to play.

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Tampa Bay Buccaneers quarterback Baker Mayfield is coming off another strong performance during last week's loss to the Atlanta Falcons. Mayfield threw for 180 yards and tossed three touchdowns as the Bucs took a tough overtime loss. The former first-round pick has thrown 11 touchdowns with only two interceptions through the first five games of the season. He'll now head into a matchup against a tough New Orleans Saints pass defense. Despite that, Mayfield has been able to overcome obstacles all season long and should be in the QB1 conversation for this Week 6 matchup.

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Las Vegas Raiders tight end Michael Mayer (personal) was placed on the reserve/non-football injury and illness list according to Field Yates of ESPN. Mayer has not suited up since Week 3 due to a personal matter and is now expected to miss more time. The Notre Dame product enjoyed a productive rookie campaign as he caught 27 passes for 304 yards and two scores. While Mayer remains away from the team, fantasy managers should expect rookie Brock Bowers to continue to see the vast majority of snaps at the position and remain a high-end option for the foreseeable future.

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Cincinnati Bengals running back Chase Brown (quadriceps) is listed as questionable for Sunday night's game against the New York Giants. Brown appeared on the injury report on Thursday after logging a limited practice session and remained in the same capacity on Friday. Earlier on Friday, head coach Zac Taylor said that Brown is expected to play. Fantasy managers should monitor his status over the weekend in case he faces a set back. Brown has seen double-digit carries in consecutive games and remains a high-upside flex option this weekend facing the New York Giants.

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Tampa Bay Buccaneers running back Rachaad White (foot) is listed as doubtful for Sunday's game according to Adam Schefter of ESPN. White opened the week as a limited participant in Wednesday's practice but was downgraded to a non-participant on Thursday and Friday which does not bode well for his status this weekend. If White is unable to suit up, fourth-round rookie Bucky Irving would get the starting nod. Irving has seen his opportunities increase over the past few weeks due to his strong efficiency as runner. If White is unable to play, fantasy managers should feel confident locking Irving into their lineup as a high-upside RB2.

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Indianapolis Colts quarterback Anthony Richardson (oblique) is expected to play in Week 6 against the Tennessee Titans barring a late-week surprise, according to Jeremy Fowler of ESPN. Richardson suffered an oblique injury in Week 4 against the Pittsburgh Steelers and was sidelined last weekend. This week, Richardson was able to log a limited practice session on Wednesday but was able to upgrade to full participation on Thursday and Friday, which suggests he should be in line to return to action. Fantasy managers should continue to monitor his status over the weekend in case he faces a setback. Richardson has struggled to remain consistent throughout his young career and remains a high-risk, high-upside QB1 against the Titans.

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Green Bay Packers wide receiver Christian Watson (ankle) is listed as questionable for Sunday's game, according to Wes Hodkiewicz. The former first-round selection was unable to suit up last week due to an ankle sprain he suffered in Week 4. This week, Watson was able to log three consecutive limited practice sessions. Fantasy managers should pay close attention to any updates over the weekend. Watson found the end zone in Week 1 but has been relatively quiet and has caught only two passes since Week 2. If Watson is able to suit up, he should be viewed as a flex option with risk given the amount of pass-catchers in the Green Bay offense, which limits his production.

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Indianapolis Colts wide receiver Michael Pittman Jr. (back) is listed as questionable for Sunday's game. Pittman did not participate in Wednesday's or Thursday's practice but was able to return in full on Friday which is a promising sign for his status for this weekend. Fantasy managers should continue to monitor his status ahead over the weekend. The USC product got off to a slow start this season but has tallied at least ten PPR points in each of his past two games with a a high of 17.3 in Week 4. If Pittman is able to suit up he should be viewed as a high-floor WR3 in PPR leagues.

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The Cleveland Browns defense has struggled this year to recapture the dominant form that made them a top fantasy defense in 2023. Things won't get any easier as they will head on the road to take on the Philadelphia Eagles in Week 6. The Eagles will be close to full strength as they will be getting A.J. Brown (hamstring) and DeVonta Smith (concussion) back this weekend. The Browns are dealing with several injuries on the defensive side of the ball, including Denzel Ward (hamstring), who has been limited in practice this week, and Myles Garrett (Achilles) who has been playing through Achilles and foot injuries. Fantasy gamers should look elsewhere for their starting defense in Week 6.

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Cleveland Browns kicker Dustin Hopkins made both of his field-goal attempts in a Week 5 loss to the Washington Commanders. The veteran kicker has now converted seven of his eight attempts this season as he gears up to face off against the Philadelphia Eagles in Week 6. The Eagles have been average against kickers this season, allowing the 15th-most fantasy points per game to the position through four games. Hopkins has been a reliable kicker but the Cleveland offense is not playing well this season, which limits his ceiling. Treat him as a low-end fantasy option heading into Week 6.

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New England Patriots running back Rhamondre Stevenson (foot) will not play on Sunday, according to Aaron Wilson of KPRC2. Stevenson was unable to practice on Wednesday and Thursday but was not seen at Friday's practice. Even though he will sit out this weekend, head coach Jerod Mayo expressed that this injury is not deemed to be serious and will not sideline Stevenson for an extended period. Fantasy managers should monitor the 26-year-old's status during next week's practices. On Sunday, Antonio Gibson should be expected to serve as the lead running back and should be viewed as a high-volume flex play against a tough Houston run defense.

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The San Francisco 49ers won't open the practice window for running back Christian McCaffrey (Achilles) this week, according to head coach Kyle Shanahan. McCaffrey is ramping up his football activities as he deals with bi-lateral Achilles tendinitis in both of his legs, but he won't return to practice next week or be available to play in Week 7 for a Super Bowl rematch against the Kansas City Chiefs. CMC remains on Injured Reserve, and the 49ers are most likely targeting a potential return for last year's Offensive Player of the Year in Week 10 against the Tampa Bay Buccaneers after their Week 9 bye. Fantasy managers must remain patient and hope the 28-year-old can return to form quickly upon his return later this season. With Jordan Mason (shoulder) suffering an AC joint sprain in Thursday night's win over the Seahawks, rookie Isaac Guerendo could be called upon to start in Week 7 versus KC.

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Cleveland Browns wide receiver Jerry Jeudy (knee) struggled in Week 5, catching just one of his three targets for 16 yards. He will look to bounce back in a plus matchup against a Philadelphia Eagles secondary that is allowing the most fantasy points per game to opposing wide receivers this season. Jeudy has been listed with a knee injury for several weeks now, but he has been practicing fully and should be without any limitations heading into Week 6. The main concern here is a struggling Cleveland passing attack headlined by Deshaun Watson. Watson has yet to throw for more than 196 yards in a game this season and has thrown for multiple touchdowns just once. Jeudy is worth a look as a WR4/flex option this weekend but fantasy managers should temper their expectations until this Cleveland passing game shows improvement.

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San Francisco 49ers rookie wide receiver Ricky Pearsall (chest) is set to have his practice window open this week according to Nick Wagoner of ESPN. The first-round pick has been sidelined with a chest injury that was caused by a gunshot wound. Once his practice window opens, the Florida product will have 21 days to get prepared to make his professional debut. Fantasy managers should expect Pearsall to be deployed as the No.3/No.4 wide receiver in the San Francisco offense when he returns. For now, he is worth stashing in deeper leagues but should be left on the waiver wire in shallow formats.

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Cleveland Browns running back Jerome Ford has seen his workload fluctuate throughout the first five games of the season. He saw the majority of the work in Weeks 1, 3, and 4 while operating in a timeshare with D'Onta Foreman in the other two weeks. With Nick Chubb (knee) already ruled out for Week 6 against the Philadelphia Eagles, Ford will have at least another week to lead the Cleveland backfield. The Eagles have been tough against running backs this season, allowing just the 26th-most fantasy points per game to the position through four games. Ford has some upside as a pass catcher but the Cleveland offense has really struggled to sustain drives this season. That fact, coupled with Ford's inconsistent workload from week to week, leaves him on the RB2/RB3 borderline in fantasy heading into Week 6.

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Cleveland Browns wide receiver Amari Cooper has struggled with drops and a lack of production for the majority of the 2024 season, going over 35 receiving yards just twice in five games. He will look to shake off his slow start in a road matchup against the Philadelphia Eagles in Week 6. Cooper did not practice on Wednesday but it was just a veteran rest day and was not injury related. The Eagles have been very generous to opposing wideouts this season, allowing the most fantasy points per game to the position through four games. It remains to be seen whether Cooper and a struggling Deshaun Watson will be able to capitalize on this plus matchup, however, as they disappointed last week against a Washington Commanders secondary that is allowing the second-most fantasy points per game. Cooper is on the radar as a WR3 in fantasy but he will be hard to trust as much more than that despite the excellent matchup.

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Cleveland Browns quarterback Deshaun Watson has struggled for much of the 2024 season, managing to throw for multiple touchdowns in just one of five games thus far. He will look to turn things around in Week 6's road matchup against the Philadelphia Eagles. The Eagles have struggled against opposing quarterbacks this season, allowing the second-most fantasy points per game to the position through four games. The plus matchup gives some optimism for Watson to have a good game, although he failed to capitalize on a similarly good matchup against the Washington Commanders last week, throwing for just 125 yards and one touchdown. The Cleveland offense looks broken with the offensive line banged up, Watson playing poorly, and the receivers struggling with drops, making it very tough to trust the Browns' quarterback in fantasy leagues this week. Treat Watson as a low-end QB2 for Week 6.

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Houston Texans running back Joe Mixon (ankle) practiced again on Friday for the second day in a row and is expected to play in Week 6 on Sunday against the New England Patriots. League sources expressed optimism that Mixon will be ready to take on a solid workload against the Patriots, barring an unexpected setback. He suffered a minor high-ankle sprain in the Week 2 win over the Chicago Bears and has missed the last three games. In addition to Mixon, it seems likely that Dameon Pierce (hamstring) will also be back against the Pats, which would push Cam Akers and Dare Ogunbowale back to the bench. In the season opener against the Colts, Mixon rushed for 159 yards and one touchdown on a career-high 30 carries. Fantasy managers shouldn't expect that type of workload on Sunday, but Mixon should at least be considered an RB2 option in his return.

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Philadelphia Eagles kicker Jake Elliott will face the Cleveland Browns in Week 6. The 29-year-old has had a slow start to the season after putting up career numbers last season. Through four games he has just four field goals converted and has done little for fantasy managers. With that said, this week's matchup against a struggling Cleveland Browns defense sets the veteran up for a bounce-back performance. The Browns are tied for the ninth-most fantasy points allowed per game to opposing kickers and the Eagles offense has regained their top two pass catchers in A.J. Brown (hamstring) and DeVonta Smith (concussion). While these additions may take some field goal opportunities off the board if they find the end zone, the Eagles should be in scoring range often. Consider Elliott a back-end K1 option in Week 6.

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Los Angeles Chargers kicker Cameron Dicker is set for another solid performance in a Week 6 game against the Denver Broncos. Dicker missed practice on Wednesday due to an illness but was able to practice in full on Thursday and won't even carry an injury designation into the game. He's only missed one field goal and one extra point attempt this season so far, making the best of the limited opportunities he's been given by the Chargers offense. The Chargers-Broncos showdown could be a defensive battle throughout, with field goals more likely drive enders than touchdowns. Dicker is a top-15 option with a high floor, although kicker can be the least predictable position in fantasy football.

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