San Francisco 49ers running back Jordan Mason (shoulder) suffered a left-shoulder injury in the first half of the Thursday night contest against the division-rival Seattle Seahawks and was deemed questionable to return. Head coach Kyle Shanahan said Mason was good to go coming out of the half, and Mason got the first touch of the third quarter before going into the blue medical tent and being sidelined again. He was seen on the sidelines with helmet on but hasn't gone back into the contest. If Mason doesn't return to the game, he will finish his night with nine carries for 73 yards (8.1 yards per carry) while catching one of two targets for a nine-yard pickup. Rookie Isaac Guerendo has picked up most of the slack in the backfield with Mason out, with receiver Deebo Samuel Sr. and Patrick Taylor Jr. also pitching in. With Christian McCaffrey (Achilles) still on Injured Reserve, Guerendo would become a priority pickup in fantasy next week if Mason's injury causes him to miss time.

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Carolina Panthers tight end Tommy Tremble (concussion) did not suit up for Thursday's practice session. Tremble has missed both practices this week after suffering a concussion during last week's loss to the Chicago Bears. Rookie tight end J'Tavion Sanders took over after Tremble's exit and hauled in three passes. Sanders could be asked to start this weekend if Tremble isn't cleared to play. He won't be a reliable streaming option though considering Tremble was barely targeted when healthy.

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San Francisco 49ers running back Jordan Mason (shoulder) has returned to action for Thursday's Week 6 matchup against the Seattle Seahawks. Mason was forced to exit during the first half after suffering a shoulder injury on a carry during the second quarter. He left the game with trainers and was held out for the rest of the half. Luckily, Mason is back now as he received the first carry of the second half. Fantasy managers can breathe a sigh of relief as it appears Mason only suffered a minor shoulder injury.

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Tampa Bay Buccaneers wide receiver Trey Palmer (concussion) missed his second straight day of practice on Thursday. Palmer sat out of last week's game as well due to a concussion. It appears the young wideout is still in concussion protocol ahead of the Week 6 matchup against the New Orleans Saints. It's worth noting that fellow wideouts Jalen McMillan (hamstring) and Kameron Johnson (ankle) are also on the injury report. That being said, Sterling Shepard could be looking at a bigger role on Sunday. He hauled in three receptions for 51 yards during the Week 3 win over the Philadelphia Eagles.

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Carolina Panthers wide receiver Diontae Johnson (ankle) was a limited participant during Thursday's practice session. This is now back-to-back practice sessions that Johnson has been limited due to a lingering ankle issue. It's worth noting that Johnson played through the ankle injury last week. He finished with three receptions for 23 yards, which was his worst performance since Week 2. It seems likely that Johnson can play through the issue, but his fantasy value could take a hit until he's back to full health. He should be on the WR3 radar for this Week 6 matchup against the Atlanta Falcons, assuming he's still banged up. If he sits, Jonathan Mingo and Xavier Leggette figure to have bigger roles in the passing game.

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San Francisco 49ers running back Jordan Mason (shoulder) is considered questionable to return during Thursday's game against the Seattle Seahawks. Mason appears to have suffered a shoulder injury during the second quarter of this Week 6 contest. He headed to the locker room with the trainers, so Mason is currently uncertain to return. He had eight carries for 65 yards before exiting the game. It wouldn't be shocking to see the 49ers hold him out until at least after halftime. That being said, Isaac Guerendo is the next man up and figures to see a majority of the snaps in the backfield.

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Tampa Bay Buccaneers running back Rachaad White (foot) was absent during Thursday's practice session. This is a downgrade for White who was limited to open the week. This is obviously not a good sign heading into Sunday's Week 6 matchup against the New Orleans Saints. However, Friday's practice will go a long way to deciding whether or not White will play this weekend. If he sits, Bucky Irving will be asked to carry the workload in the backfield. He'd move into RB2 territory if White is unable to play this weekend.

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Jacksonville Jaguars running back Travis Etienne Jr. (shoulder) continues to work his way through a shoulder injury and was limited in practice for the second straight day this week on Thursday. Etienne was also limited in all three practices last week before suiting up in the Week 5 win over the division-rival Indianapolis Colts, but he played a season-low 38% of the offensive snaps and saw backfield mate Tank Bigsby once again outproduce him after aggravating his shoulder and missing some time. Head coach Doug Pederson said Etienne is still the team's featured back, but given his injury and Bigsby's performances in recent weeks, it seems likely that Etienne will continue to lose valuable touches to Bigsby moving forward. He should be active this Sunday in London against a tough Chicago Bears defense, where he should be considered a low-end RB2 with limited upside.

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Jacksonville Jaguars wide receiver Gabe Davis (knee) was limited in practice for the second straight day this week on Thursday. Davis should be just fine to play this Sunday in Week 6 in London against the Chicago Bears, but he won't be recommended in starting fantasy lineups, especially if tight end Evan Engram (hamstring) returns for the first time since Week 1. He played the most snaps among the team's wideouts in the Week 5 win over the division-rival Indianapolis Colts, but it led to only three receptions (four targets) for 38 yards. The former Buffalo Bills wideout has yet to find the end zone in his first year in Jacksonville in 2024 and is outside the top 50 at the position in total fantasy points through the first five weeks. The Bears defense has also allowed the seventh-fewest fantasy points per game to opposing wideouts this year. Davis belong on benches or the waiver wire in Week 6.

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Jacksonville Jaguars tight end Evan Engram (hamstring) was listed as limited in practice for the second straight day this week on Thursday. Engram hasn't played since the season-opening loss to the Miami Dolphins after injuring his hamstring during pre-game warmups before Week 2, but head coach Doug Pederson said earlier this week that he's optimistic that the 30-year-old will be able to return this Sunday to face the Chicago Bears in London. For what it's worth, Engram was also limited all of last week before being held out of the Week 5 win over the division-rival Indianapolis Colts. Jacksonville could ease Engram back into the fold if he's active in London, making him a shaky low-end TE1 for fantasy managers if he plays. Backup Brenton Strange has two touchdowns in four games without Engram and would once again be a TE2 streamer if Engram is held out for a fifth straight game.

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San Francisco 49ers rookie first-round wide receiver Ricky Pearsall (chest) will resume practicing next week. Pearsall might have had his practice window opened this week if not for a quick turnaround with a Thursday night tilt in Week 6 against the division-rival Seattle Seahawks. The 24-year-old will instead return to practice next week, and the 49ers will have 21 days to activate him from the Non-Football Injury list. Pearsall missed a good chunk of time in training camp with a hamstring injury and then was shot in the chest during a robbery attempt right before the start of the regular season. It's great news that Pearsall is nearing a return to practice, but we'd expect the Niners to use the full 21-day window to get him up to speed. And when Pearsall does, he'll be battling for snaps behind Deebo Samuel Sr., Brandon Aiyuk and Jauan Jennings. Pearsall is a dynasty/keeper stash, at best.

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San Francisco 49ers running back Christian McCaffrey (Achilles) is targeting an early November return from Injured Reserve. McCaffrey was technically eligible to come off IR to play on Thursday night in Week 6 against the Seattle Seahawks, but that was never going to happen. The fact that CMC has yet to practice means he still has a ways to go before he can even think about making his 2024 debut. Fantasy managers obviously can do nothing but hope McCaffrey returns sooner than later and keep him stashed in an IR spot. In the meantime, Jordan Mason, who has been one of the league's leading rushers through five weeks, will continue to serve as San Fran's lead back. Mason is the RB5 in half-PPR scoring heading into Thursday night's game against Seattle and should be deployed in all fantasy starting lineups against a beat-up defense.

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Green Bay Packers tight end Tucker Kraft (groin) popped up on the Week 6 injury report on Thursday after putting in a limited practice. Mid-week additions to the injury report usually are never good, so fantasy managers sticking with Kraft after his big Week 5 performance will want to monitor his status heading into the Week 6 contest versus the Arizona Cardinals. Fellow tight end Luke Musgrave (ankle) is expected to land on Injured Reserve this week, so if Kraft is unable to play on Sunday, the Packers would be down to Ben Sims and John FitzPatrick at the position. Kraft benefitted from both receivers Christian Watson (ankle) and Romeo Doubs (suspension) being out in last week's win over the Los Angeles Rams, catching four passes for a season-high 88 yards and two touchdowns. He has three TDs in the last two games and has become a bigger part of the offense, although that could change with Doubs and potentially Watson both returning in Week 6.

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Green Bay Packers wide receiver Christian Watson (ankle) put in his second limited practice of the week on Thursday. Watson is making good progress after suffering a left high-ankle sprain in the Week 4 loss to the division-rival Minnesota Vikings. He did not play in last Sunday's win over the Los Angeles Rams, but two limited practices this week has put the 25-year-old in play to potentially return for Week 6 versus the visiting Arizona Cardinals. Watson is probably going to need to upgrade to a full practice on Friday to avoid a questionable tag on the final injury report. Even if Watson is active this weekend, he'll be a shaky flex play for fantasy managers with a potential cap on his snaps as he works his way back into the fold in a crowded receiver picture in Green Bay. A second straight missed game would mean more targets for Jayden Reed, Romeo Doubs and Dontayvion Wicks.

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Indianapolis Colts running back Trey Sermon (collarbone) was held out of Wednesday's practice but was a full participant just a day later on Thursday. Sermon was a popular waiver-wire pickup last week after Jonathan Taylor suffered a high-ankle sprain in the Week 4 win over the Indianapolis Colts. Taylor did not play in the Week 5 loss to the division-rival Jacksonville Jaguars, and Sermon took advantage as the lead back to record 10 carries for 38 yards and a touchdown while adding six catches for an extra 25 yards. Taylor has not practiced this week and appears headed for a second straight absence, which will put Sermon back into flex territory against the Titans. The 25-year-old won't have as much fantasy upside, though, against a Titans defense allowing the 22nd-most half-PPR points to RBs through five weeks. The impending return of quarterback Anthony Richardson (oblique) is also probably bad news for Sermon's rushing chances.

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Updating a previous report, Indianapolis Colts quarterback Anthony Richardson (oblique) was a full participant in Thursday's practice and was looking spry after being limited on Wednesday. Richardson injured his oblique in the Week 4 win over the Pittsburgh Steelers and didn't suit up for the Week 5 loss to the division-rival Jacksonville Jaguars. With a full practice under his belt this week, the 22-year-old second-year signal-caller is trending toward returning for this Sunday's divisional clash with the Tennessee Titans against a tough secondary. However, fantasy managers shouldn't be looking to throw him immediately back into starting lineups if he's active in Week 6, especially if he's without running back Jonathan Taylor (ankle) and receivers Michael Pittman Jr. (back) and Josh Downs (toe). Richardson has been a disappointment through four games in 2024 as both a runner and a passer.

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San Francisco 49ers wide receiver Chris Conley (oblique) is officially active for the Thursday night divisional showdown against the Seattle Seahawks at Lumen Field to kick off Week 6 action. Conley came into the game listed as questionable, but he will suit up. Meanwhile, cornerback Charvarius Ward (knee) is inactive and won't play. Conley is making his return after missing the Week 5 loss to the division-rival Arizona Cardinals. The 31-year-old veteran has caught only one pass on three targets for a four-yard gain in four games played in 2024. Fantasy managers can continue to ignore Conley as he serves as receiver depth in San Francisco. Conley's return in Week 6 could mean less opportunities for rookie Jacob Cowing and Ronnie Bell.

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Philadelphia Eagles wide receivers A.J. Brown (hamstring) and DeVonta Smith (concussion) are both on track to return to action in Week 6 against the Cleveland Browns after putting in a second straight day with a full practice on Thursday. Brown hasn't played since catching half of his 10 targets for 119 yards and a touchdown in the Week 1 win over the Green Bay Packers in Brazil, but he's made nice progress coming out of the bye week and should be returned to all starting fantasy lineups for a tilt against Cleveland this Sunday in Philly. Smith suffered a concussion in Week 3 and was held out of the Week 4 loss to the Tampa Bay Buccaneers. He, too, should be returned to all fantasy lineups, although he still needs to gain final clearance from the concussion protocol. The return of both Brown and Smith is bad news for tight end Dallas Goedert but is great news for quarterback Jalen Hurts' fantasy value.

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The Athletic's Matt Barrows writes that San Francisco 49ers quarterback Brock Purdy and the team clearly aren't looking for running back Jordan Mason as a receiver out of the backfield. Mason is still building his chemistry with Purdy as the team's lead back in 2024 with Christian McCaffrey (Achilles) injured. No RB who has run at least 50 pass routes has been targeted less than Mason this year. A lot of that could have to do with the fact that the Niners don't actually have a third-down option at the position. Although Mason has just seven receptions for 66 yards in five games this year, he's the RB5 in half-PPR scoring into the team's Thursday night divisional showdown against the Seattle Seahawks at Lumen Field. Mason lost the first fumble of his career in the Week 5 loss to the Arizona Cardinals but still had 89 rushing yards on 14 carries. He's a must-start in Week 6 on Thursday night in fantasy.

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Atlanta Falcons running back Bijan Robinson (hamstring) was added to the Week 6 injury report after putting in a limited practice on Thursday. Robinson was a full-go on Wednesday. His downgrade on Thursday is most likely just the Falcons giving him a little rest as the team prepares to take on the division-rival Carolina Panthers in Week 6. The 22-year-old was also listed with a hamstring injury before last Thursday's win over the Tampa Bay Buccaneers, but he played and handled 15 touches for 77 scrimmage yards. Drafted in the first round in fantasy drafts this year, Robinson has been a bust so far as the RB21 in half-PPR scoring through the first five weeks. However, he won't have a better bounce-back opportunity this weekend than against the 1-4 Panthers, as they have allowed the most points to opposing RBs this year. Bijan is a must-start in all lineups.

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