Manuel Margot doubled and matched a career high with five RBIs as the Minnesota Twins cruised to an 11-1 win over the Seattle Mariners on Thursday in Minneapolis.

Max Kepler and Ryan Jeffers homered and drove in two runs apiece for Minnesota, which won three of four games in the series. Carlos Santana and Edouard Julien each drove in one run.

Twins starter Pablo Lopez (4-2) limited Seattle hitters to one run on four hits in 6 1/3 innings. Lopez walked none and struck out 10.

Luke Raley finished 2-for-4 with an RBI to lead Seattle at the plate. Logan Gilbert (3-1) gave up eight runs on nine hits in four innings.

Brewers 7, Cardinals 1

Rhys Hoskins' two-run shot in the first inning was one of three homers off Sonny Gray as Milwaukee handed visiting St. Louis a fifth straight loss.

Jake Bauers and Joey Ortiz also had solo homers off Gray (4-2), who entered with a 0.89 ERA and had allowed just one homer in his first five starts. William Contreras and Christian Yelich each had three hits and an RBI for Milwaukee.

Lars Nootbar homered for the Cardinals. Gray allowed six runs on seven hits, a walk, a wild pitch and a hit batter in five innings.

Diamondbacks 5, Reds 4

Tucker Barnhart haunted his former team by starting a game-winning rally with two outs in the eighth inning as visiting Arizona completed a three-game sweep of Cincinnati.

Corbin Carroll broke a 4-4 tie with a two-out hit off Fernando Cruz (1-3) in the eighth to score Barnhart and give the Diamondbacks their season-best fourth straight win. Joc Pederson homered with two outs in the first to snap Cincinnati starter Hunter Greene's career-high scoreless streak at 14 2/3 innings.

Elly De La Cruz went 2-for-3 with an RBI for Cincinnati, which lost its eighth straight. De La Cruz had two more steals to give him a major-league-leading 23.

Rockies 9, Giants 1

Brenton Doyle homered among his two hits, Ezequiel Tovar tripled and doubled in the fourth inning and finished with three hits, and Colorado beat San Francisco in Denver.

Charlie Blackmon tripled, doubled, singled and drove in two runs, Elias Diaz had two hits for the Rockies, who sent 11 batters to the plate in a seven-run fourth inning. Cal Quantrill (2-3) tossed six innings of one-run ball to help Colorado end a four-game skid.

Michael Conforto homered for the Giants, who failed in a bid for a three-game sweep. Keaton Winn (3-5) allowed seven runs in 3 2/3 innings.

Astros 4, Yankees 3

Jon Singleton hit a 442-foot, two-run homer to cap a three-run first inning as visiting Houston stopped a nine-game, head-to-head losing streak against New York.

Singleton helped the Astros strike early against New York's Marcus Stroman (2-2) by hitting a 1-0 sinker off an advertisement on the third deck in right field. Yordan Alvarez preceded Singleton's blast with a 395-foot drive into the second deck in right field.

Anthony Volpe hit a two-run homer that just cleared the right field fence in the third, but the Yankees saw a five-game win streak stopped. Aaron Judge hit a 473-foot homer in the eighth off Ryan Pressly, but Josh Hader closed it out, getting four outs for his fourth save.

Royals 10, Angels 4

Michael Wacha took a shutout into the seventh inning, Vinnie Pasquantino and Dairon Blanco homered and Kansas City downed Los Angeles in Anaheim, Calif.

Wacha (2-4) wound up going six-plus innings, allowing three runs, two earned. Maikel Garcia had three hits, scored twice and drove in two. Pasquantino finished with three hits and three RBIs, and Blanco had three hits, four runs and two RBIs.

Cole Tucker knocked in two runs for the Angels, while Reid Detmers (3-4) gave up six runs in five innings.

White Sox 3, Guardians 2

Erick Fedde held visiting Cleveland scoreless over six-plus innings as Chicago won the opener of a four-game series.

Fedde (3-0) allowed six hits and no walks while striking out three. Eloy Jimenez broke out of a 4-for-33 slump with two hits for Chicago, which won for the fourth time in six games.

Josh Naylor, Will Brennan and Bo Naylor each had two hits for Cleveland, which went 1-for-8 with runners in scoring position. Ben Lively (1-2) allowed three runs over 5 2/3 innings.