Gerrit Cole and Max Fried have been teammates since last season but never in the New York Yankees' rotation at the same time because of injuries.

That changes Wednesday when Cole and Fried start for New York in its day-night doubleheader with the visiting Pittsburgh Pirates.

Cole (3-5, 3.93 ERA) will start the opener on Wednesday afternoon against fellow right-hander Mitch Keller (6-7, 5.14). Fried (4-3, 3.21), a left-hander, will return from a bone bruise in his left elbow for his first start since May 13 when he faces righty Bubba Chandler (3-8, 4.77) in the second game.

Cole was recovering from Tommy John surgery on his elbow last season when Fried was 19-5 with a 2.86 ERA in the first year of an eight-year deal. They were set to be on the roster at the same time May 22 when Cole made his season debut but Fried went on the injured list on May 14 after his velocity diminished in a three-inning start at Baltimore one day earlier.

Cole is 1-4 with a 5.33 ERA in his past five starts and pitched six scoreless innings before Max Muncy hit a slider for a go-ahead two-run homer two batters into the seventh inning of Friday's 2-1 loss to the Dodgers.

Fried threw 52 pitches in his first rehab start for Triple-A Scranton/Wilkes-Barre and was slated for another before the Yankees decided to activate after Tuesday's game was rained out. In the start before getting hurt, Fried allowed five runs on six hits in six innings during a loss at Milwaukee on May 8.

Cole is 1-0 with a 2.45 ERA in a pair of starts against Pittsburgh, which drafted him first overall in 2011. Fried is 4-1 with a 3.94 ERA in eight career starts against the Pirates.

The duo is pitching in New York's second doubleheader in four days after the Yankees opened the series with Monday's 8-5 victory. Jazz Chisholm is hitting .368 (7-for-19) in his past five games after homering twice and driving in five runs.

"He's capable of that," Yankees manager Aaron Boone said of Chisholm, who batted .177 in 25 games last month and is hitting .228 overall. "When he gets it rolling, he's capable of big things."

The Pirates are playing their third doubleheader this month. Pittsburgh earned a pair of one-run victories when it swept a doubleheader from visiting Milwaukee on July 11 and split two games in Cleveland on Saturday.

Pittsburgh is 8-4 in its past 12 and has scored at least five runs in nine of those games.

Rookie Esmerlyn Valdez hit a two-run homer, has an RBI in eight straight games and is the first Pirate with an RBI and an extra-base hit in eight games in a row since Hall of Famer Willie Stargell in 1971.

He also is hitting .369 with 11 of his 13 homers and 29 RBIs over his past 23 games since June 19.

"It's a product of my preparation during the offseason," Valdez said through an interpreter. "Hopefully, that's not the only achievement I'm going to do. I'm going to do hopefully more in a Pirates uniform."

After getting a short outing from Braxton Ashcraft on Monday, the Pirates hope Keller starts reversing his recent struggles. After allowing three runs in three innings during a 10-5 loss to Atlanta on July 9, Keller is 1-5 with a 7.61 ERA in his past eight starts.

Keller is 0-2 with a 10.24 ERA in two career starts against the Yankees.

Chandler, who is 2-2 with a 4.68 ERA in his past starts, will make his first appearance against the Yankees. In his most recent start, the right-hander allowed two runs on five hits in 4 2/3 innings while throwing 97 pitches in a no-decision during the Pirates' 3-2 home win over the Brewers on July 11.