The Toronto Blue Jays will be out to salvage what they can from a guaranteed losing homestand Wednesday night when they continue their series with the Tampa Bay Rays.

The Blue Jays dropped to 1-4 on their seven-game homestand with a 12-2 setback to the Rays on Tuesday.

Tampa Bay is 7-1 against Toronto this season to clinch the season series.

While the Rays sit atop the American League East, the Blue Jays are last in the division, with their hopes of a wild-card spot fading.

"I think everyone is frustrated," Blue Jays manager John Schneider said. "There's no secret, this is not going to be easy. It's going to be hard. You just want to find some small wins for one, and two, you just make sure everyone understands that this is going to be hard and you've got to dig your way out of this."

The Blue Jays have only eight runs over their first five games since returning from the All-Star break.

After the Rays scored three runs in the first inning Tuesday against Kevin Gausman, the Blue Jays failed to score against Drew Rasmussen in the bottom of the inning despite loading the bases with one out. That is a microcosm of Toronto's season.

Vladimir Guerrero Jr. was 0-for-4 on Tuesday and is in an 0-for-13 funk in a disappointing season. The Rays' pitchers have been tough on Guerrero this season, holding him at 2-for-27.

The Blue Jays' defense also has been a problem against the Rays. Toronto has committed five errors over the two games of the four-game series.

That number could have been higher. One error call on Tuesday -- third baseman Kazuma Okamoto on Nick Fortes' grounder in the seventh -- was changed to a hit.

Schneider said the fielding mistakes are more a result of the Rays' style than his team pressing.

"This team really plays the game fast," Schneider said of Tampa Bay. "I don't think that it's us playing tight. I think it's them forcing the issue."

The Rays also have been hitting for power in the series. They had three homers on Monday. Fortes, who went deep in his second consecutive contest, joined Yandy Diaz -- who was playing in his 1,000th MLB game -- by belting a three-run homer on Tuesday.

"That's pretty special to play 1,000 games at this level, and he's done it at an incredibly high level," Rays manager Kevin Cash said of Diaz. "I appreciate Yandy, certainly the hitter he is, the way he's evolved as a teammate, as a leader on this team, the energy that he provides on a daily basis, and the way he carries himself is really special."

Chandler Simpson and Ben Williamson each had four hits for Tampa Bay, and Junior Caminero had two hits and three walks. The Rays had a season-best 21 hits.

"It just attests to everything that we can do in the lineup," Simpson said. "We can win it with speed, put the bat on the ball. We can also use the power game as well to win games."

The Blue Jays will go with an opener on Wednesday, with right-handed reliever Braydon Fisher (3-3, 3.65 ERA) getting the call. In 10 career relief appearances against the Rays, he is 1-1 with a 2.08 ERA.

Right-hander Griffin Jax (5-7, 4.08) is Tampa Bay's scheduled starter on Wednesday. He is 1-2 with a 3.80 ERA in 17 career games (two starts) against Toronto.