Joey Ortiz delivered a walk-off single with one out in the 11th inning, giving the Milwaukee Brewers a 7-6 victory over the visiting New York Yankees on Friday in the opener of a three-game series.

Pinch runner Owen Miller advanced to third on Brice Turang's leadoff flyout to open the 11th against Michael Tonkin (1-3), who was claimed on waivers by the Yankees from the Mets on Thursday. Ortiz then lined the game-winner to left.

The Yankees failed to score in the top of the 11th when pinch runner Jahmai Jones was thrown out trying to come home from third on a one-out comebacker to the mound.

Giancarlo Stanton put the Yankees ahead 6-5 by leading off the 10th with a pinch-hit RBI double. The Brewers tied it in the bottom half when William Contreras advanced to third on a passed ball and Willy Adames followed with an RBI single.

Giants 3, Pirates 0

Patrick Bailey crushed a walk-off, three-run homer with no outs in the bottom of the ninth inning, producing the only scoring of San Francisco's victory over Pittsburgh.

After Camilo Doval (2-0) had pitched out of a bases-loaded jam in the top of the inning, Pirates closer David Bednar (1-2) walked Michael Conforto and served up a single to Matt Chapman to start off the bottom of the inning. Giants starter Kyle Harrison shut out Pittsburgh on five hits over the first six innings.

The Pirates threatened in the top of the ninth against Doval, loading the bases on singles by Oneil Cruz and Michael Taylor and a one-out walk by Andrew McCutchen. Doval turned a comebacker from Bryan Reynolds into a 1-2-3 double play to preserve the tie. Pirates starter Quinn Priester allowed just three singles in his six shutout innings.

Athletics 3, Orioles 2 (10 innings)

Brent Rooker hit an RBI double to drive in the go-ahead run in extra innings as visiting Oakland rallied past Baltimore in 10 innings to open a three-game series.

Rooker finished 2-for-4 with two doubles, an RBI and a run scored. Shea Langeliers hit a home run and Lawrence Butler added a double for Oakland. Mason Miller pitched a perfect 10th inning and struck out Gunnar Henderson with the tying run on third to secure his seventh save of the season and the Athletics' second straight win.

Ryan O'Hearn had two singles and an RBI, and Cedric Mullins hit his sixth home run of the season for the Orioles, who led 2-1 entering the ninth inning.

Cubs 7, Red Sox 1

Michael Busch went 3-for-4 while rookie Pete Crow-Armstrong recorded his second straight multi-RBI game to help visiting Chicago beat Boston.

Cubs rookie Shota Imanaga (4-0) struck out seven and allowed just one run in 6 1/3 innings. Crow-Armstrong, Christopher Morel and Dansby Swanson had two hits apiece in Chicago's fourth straight win.

Tyler O'Neill went 2-for-4 and drove in the Red Sox's lone run with a fourth-inning homer. Kutter Crawford (1-1) allowed four runs (three earned) on 10 hits in six innings.

Dodgers 12, Blue Jays 2

Max Muncy hit a three-run home run, right-hander Gavin Stone pitched seven strong innings and visiting Los Angeles defeated Toronto.

Shohei Ohtani and Will Smith added solo homers for the Dodgers, who won the opener of the three-game series to extend their winning streak to five games. Smith had four hits and Muncy had three to lead the Dodgers' 19-hit attack.

Danny Jansen hit a solo home run for the Blue Jays, who have lost four straight.

Nationals 3, Marlins 1

Joey Meneses lined a go-ahead, two-run single to center in the eighth inning as Washington defeated host Miami.

The Nationals also got two hits each from Trey Lipscomb and Jacob Young -- their eighth and ninth hitters in the lineup -- and four scoreless innings from their bullpen.

Anthony Maldonado made his major league debut for the Marlins, starting the game and pitching three scoreless innings. He had been Miami's closer at Triple-A this year.

Royals 8, Tigers 0

Seth Lugo pitched seven dominant innings and visiting Kansas City scored seven ninth-inning runs to notch a shutout victory over Detroit.

Lugo (4-1) allowed only three hits and tied his career-best with nine strikeouts. John Schreiber and Will Smith completed the shutout. Bobby Witt Jr. drove in three runs and Maikel Garcia knocked in a pair during the opener of the three-game series. Adam Frazier scored two runs, drove in another and made a sparkling defensive play.

Detroit starter Reese Olson (0-4) limited the Royals to one run and three hits in seven innings.

Cardinals 4, Mets 2

Miles Mikolas combined with three relievers to lift visiting St. Louis over New York in the opener of a three-game series.

Mikolas (2-3) allowed two runs on seven hits and no walks while striking out five over 5 2/3 innings. Alec Burleson and Willson Contreras homered for the Cardinals, who have won three of four.

Tomas Nido had two hits, including a homer, for the Mets, who have lost four of five. J.D. Martinez had an RBI double among two hits in his Mets debut. Martinez, a lifetime .287 hitter with 315 career homers, was recalled from Triple-A Syracuse prior to the game.

Twins 5, Angels 3

Carlos Santana went 2-for-4 with a homer and two RBIs as Minnesota held on for a win over Los Angeles in Anaheim, Calif.

Willi Castro finished 3-for-4 with two doubles, an RBI and two runs for Minnesota, which won its fifth game in a row. Bailey Ober (2-1) allowed two runs in 7 1/3 innings. Caleb Thielbar escaped a jam in the ninth for his first save.

Zach Neto was 3-for-4 with two doubles and an RBI for the Angels, who lost for the seventh time in their past eight games. Patrick Sandoval (1-4) gave up four runs (three earned) in 5 2/3 innings.

Braves 6, Guardians 2

Chris Sale threw seven masterful innings and Ozzie Albies returned from the injured list to get two hits and help Atlanta beat visiting Cleveland in the opener of a three-game series.

The Braves have won four in a row and 10 of their past 11. Atlanta and Cleveland are now tied with a major-league-best 18 wins.

Guardians starter Logan Allen (3-1) pitched 4 2/3 innings and allowed four runs on five hits and two walks while striking out five.

White Sox 9, Rays 4

Martin Maldonado and Eloy Jimenez homered and Chris Flexen pitched effectively into the sixth inning as host Chicago Sox beat Tampa Bay to stop a seven-game losing streak.

The White Sox won for just the fourth time in 26 games while sending Tampa Bay to its fourth loss in five games.

Zach Eflin (1-3) scattered five runs, four earned, and nine hits in six innings with two walks and four strikeouts for the Rays.

Rangers 2, Reds 1

Marcus Semien hit a go-ahead solo home run in the bottom of the eighth to lead Texas past Cincinnati in the opener of a three-game series in Arlington, Texas.

Evan Carter also homered and had two hits and Leody Taveras had a double and two hits for the Rangers, who won for just the third time in their past seven games.

Jonathan India had two hits and Elly De La Cruz had two walks, two stolen bases and a run scored for the Reds, who suffered their second straight loss.

Phillies 9, Padres 3

Kyle Schwarber led off the game with the first of five Philadelphia homers and Aaron Nola worked eight solid innings as the Phillies rolled to a road rout of San Diego.

Brandon Marsh, Bryce Harper, Nick Castellanos and J.T. Realmuto also went deep for the Phillies, who earned their second win in a row and improved to 9-2 in their past 11 games. Alec Bohm and Marsh each had three hits, and Realmuto went 2-for-4.

Rookie Graham Pauley homered and Luis Campusano collected two hits for the Padres, who took their second loss in three games.

Mariners 6, Diamondbacks 1

Mitch Haniger hit a grand slam and Emerson Hancock pitched six quality innings as Seattle defeated visiting Arizona in the opener of a three-game interleague series.

Josh Rojas and Mitch Garver added solo shots for the American League West-leading Mariners, who have won eight of their past 10 games.

Kevin Newman hit a solo homer for the Diamondbacks, who lost for the sixth time in nine games.