Houston Texans running back Joe Mixon (ankle, foot) is not expected to play this season as he deals with a foot injury from the offseason, according to Ian Rapoport of NFL Network. Mixon will likely stay on the Physically Unable to Perform list through the end of the 2025 season, while the Texans move forward with veteran Nick Chubb and rookie Woody Marks in their backfield. Things had been trending this way for a while, as the Texans haven't been giving any real updates on Mixon for pretty much the entire season. Fantasy managers who are still stashing the 29-year-old in redraft leagues should send him to the waiver wire now. Mixon's injury dates all the way back to spring workouts. One would think he'd be ready for the start of the 2026 campaign, but there has been little information about the exact nature of his injury. Marks, a fourth-rounder in April, has slowly started to see more work and should be the backfield leader over Chubb by the end of the year.

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Tampa Bay Buccaneers wide receiver Chris Godwin (leg) was spotted at Thursday's practice, per FOX Sports' Greg Auman. The veteran's practice status was not detailed. Although Godwin was not seen at Wednesday's session, he was out there in a limited capacity, a trend that's continued since he hit the field ahead of their Week 11 loss to Buffalo. As it stands, it's unknown if the ninth-year pro will be active for this Sunday's road outing with the Los Angeles Rams. Considering how the Buccaneers have handled him thus far in the season, it's fair to wonder if he came back from his 2024 ankle injury at too expedited a pace. If he can't suit up again, fantasy managers can expect Emeka Egbuka (illness), Tez Johnson, and Sterling Shepard (shoulder) to remain the team's top three wideouts.

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Tampa Bay Buccaneers running back Bucky Irving (foot, shoulder) was at practice again on Thursday as the team gears up for its Sunday night road matchup with the Los Angeles Rams. Irving returned to practice in Week 11, although he was unable to suit up for their loss to the Bills after a week's worth of limited sessions. Tampa Bay has played it slow with the 23-year-old, but it would appear he's on track to at least have a shot at playing this weekend. Fantasy managers will have to keep a watchful eye on this situation, as if he's forced to sit for a seventh straight game, backfield mate Sean Tucker would be an intriguing play considering his efficiency over the previous three weeks. We'll know more about Irving's Week 12 designation following practice on Friday.

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Las Vegas Raiders wide receiver Tre Tucker is on the WR3/flex radar for Week 12's home outing with the Cleveland Browns this Sunday. The University of Cincinnati product posted his first touchdown since Week 3 in Monday night's 33-16 loss to the Cowboys, reeling in 4-of-8 targets for 47 yards, while quarterback Geno Smith struggled against the Dallas defense. Smith's inconsistencies have hindered Las Vegas' attack, although Tucker has remained involved as the clear-cut second option behind tight end Brock Bowers in the passing game. Cleveland's defense isn't the most favorable of matchups, but Tucker's floor has risen modestly since the departure of ex-teammate Jakobi Meyers. Additionally, he's always just one big play away from a viable fantasy performance. Tucker is RotoBaller's PPR WR33 ahead of Sunday's clash.

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Houston Texans wide receiver Jayden Higgins is on the rise ahead of his Week 12 meeting with the visiting Buffalo Bills on Thursday Night Football. Higgins hasn't exactly had a breakout performance yet in his rookie campaign. However, signs point to him ascending the WR hierarchy in Houston. Since Week 8, the Iowa State alum has played more snaps than third-year pro Xavier Hutchinson in all but one outing, signaling a shift from earlier in the season. In fact, he's run the most plays of any Houston wideout in that time frame, posting at least four catches and seven targets in three of four games. Higgins could still exhibit some inefficiencies as he continues to adjust to life in the NFL. With that said, he's evolved into the clear third option in an offense that attempts a pass at the ninth-highest rate (59.91%).

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Los Angeles Rams quarterback Matthew Stafford is an excellent start for fantasy managers this weekend when he lines up with the Tampa Bay Buccaneers on Sunday Night Football. Stafford has been incredible in 2025, having already eclipsed his touchdown totals from the previous three seasons. Since Week 4, the 37-year-old has racked up a 22:0 TD:INT ratio, and has averaged 22.4 fantasy points per contest (fourth-most). On Sunday, he'll get another chance to keep his hot streak alive against a Buccaneers' defense that's allowed the eighth-most fantasy points per game to QBs (19). While the veteran had a down performance in their win over Seattle last weekend, his outlook is back on the rise with wide receiver Davante Adams further removed from an oblique injury.

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Baltimore Ravens tight end Mark Andrews has come alive in the last three weeks. After a slow start to his eighth season in the NFL, Andrews has scored four touchdowns in his previous three games, averaging 12.9 half-PPR fantasy points per game. The clear correlation is the return of two-time MVP Lamar Jackson, who made his return in Week 9, where Andrews scored two touchdowns. As long as Jackson is the starting quarterback in Baltimore, Andrews will continue to find the endzone and produce fantasy matchup-altering performances. In the next two games, the Ravens face the Jets and the Bengals, who have allowed the most and second-most touchdowns to tight ends this season. While his lack of volume is concerning, Andrews will still be worth starting in fantasy due to his touchdown upside.

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Indianapolis Colts wide receiver Alec Pierce has become a trustworthy option for fantasy managers this season. In eight games, Pierce has hauled in 28 of 52 targets for 585 yards and a touchdown, averaging 9.8 half-PPR points per game. As of late, Pierce has been dominant, leading the NFL in receiving yards (366) from Week 7 to Week 10. His connection with Daniel Jones has been on point this season, and the Colts' offensive performance has opened more big-play opportunities for the deep threat receiver. However, he faces a very tough matchup against the Kansas City Chiefs, who have allowed the fewest receiving yards to wide receivers in 2025. While a tough matchup causes a lot more risk, Pierce is worth starting as a WR3/FLEX play in Week 12.

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Arizona Cardinals quarterback Jacoby Brissett has been facilitating as the Cardinals' starting quarterback. In five starts, Brissett has averaged over 300 passing yards per game with multiple touchdowns in all five starts. The veteran quarterback set the completions record in Week 11, with 47 completions in the 41-22 loss to the San Francisco 49ers. Not only has Brissett been an elite producer lately, but players like Trey McBride, Marvin Harrison Jr., and Michael Wilson have also been reaping the benefits of his stellar play. Brissett and the Cardinals host the Jacksonville Jaguars in Week 12, who have allowed the seventh-most passing yards per game and the fourth-most passing touchdowns in 2025. Even with Marvin Harrison Jr. (appendicitis) ruled out for Sunday, Brissett still carries QB2 value and will continue to supply big performances for McBride and Wilson.

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Washington Commanders running back Chris Rodriguez Jr. was the lead back in Week 11, handling 15 carries for 79 yards in the overtime loss to the Miami Dolphins. Rumors were swirling about Rodriguez taking over the backfield from rookie Jacory Croskey-Merritt, and he was efficient in his first game as the lead back. Rodriguez played 45% of the snaps, while Croskey-Merritt and receiving back Jeremy McNichols played 26% of the snaps each. While the Commanders' offense has been lackluster to say the least, reinforcements are on the way, with Jayden Daniels (elbow) and Terry McLaurin (quad) nearing a return. If the offensive production improves, Rodriguez could be a sneaky producer for fantasy managers down the stretch.

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Denver Broncos rookie running back R.J. Harvey could handle a workhorse role for the rest of the season. In his first game as the lead back, Harvey handled 11 carries for 30 yards, while adding 20 yards on three receptions through the air. His first game as the starter came against the Kansas City Chiefs, who have been a top-five run defense in 2025. The exciting news about the 2025 second-round pick's fantasy outlook is that he dominated the snap share in Week 11. He played a season-high 62% of the snaps, while Jaleel McLaughlin and Tyler Badie played 13%. Coming out of the bye week, the Broncos will face the Washington Commanders, who have given up the third-most fantasy points to running backs this season. With a strong workload and a good schedule coming out of the bye week, Harvey is an ideal buy-low candidate for fantasy managers and could be a league winner down the stretch.

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Los Angeles Chargers rookie running back Omarion Hampton's practice window is expected to open after the Week 12 bye. Hampton (ankle) was placed on the injured reserve after suffering an ankle injury against the Washington Commanders. Head coach Jim Harbaugh shared that Hampton's activation window could open after the bye, but he was uncertain about a return in Week 13. When Hampton returns, he could enter a timeshare with standout Kimani Vidal, who's been excellent as his replacement. Hampton was starting to pick up steam in his rookie season, averaging 121.3 scrimmage yards and two touchdowns in his last three games when healthy. While a potential committee is in the works, and the Chargers' struggles with the offensive line, Hampton still offers elite upside once he returns.

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Buffalo Bills tight end Dawson Knox should not be relied upon in most formats when his team takes on the Houston Texans in Week 12, even with fellow tight end Dalton Kincaid (hamstring) ruled out for the game. As the team's top tight end option last week, Knox managed only one catch for 23 yards, bringing him to just 13 catches on the year. Additionally, the Texans have been among the very best pass defenses in the NFL so far this season. Houston ranks fourth overall against half-PPR tight ends, dampering an already modest outlook for Knox. The veteran will have some red-zone appeal, however, making him a low-end TE2 option in leagues that start more than one tight end.

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Coming off the best game of his career, Buffalo Bills wide receiver Tyrell Shavers should be left on the bench in most formats when his team takes on the Houston Texans on Thursday. Shavers, mostly a special teamer to this point, broke out for four catches, 90 yards, and a touchdown last week against Tampa, and now the Bills' receiver room is in limbo this week. Khalil Shakir (personal) missed practice on Monday and Tuesday, while Keon Coleman was a healthy scratch last week after being late to a team meeting. If either or both were to be unavailable tonight, that would leave some combination of Shavers, Joshua Palmer, Curtis Samuel, and Mecole Hardman to fill in the gaps. Even so, Shavers has just 11 catches in 10 games overall, and Houston ranks No. 1 against PPR receivers, making him too risky to rely upon.

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Buffalo Bills wide receiver Khalil Shakir enters a Week 12 matchup against the Houston in unknown territory after missing practice on both Monday and Tuesday for personal reasons. Assuming Shakir plays, he's a low-end WR3 option against Houston, the top-ranked defense against PPR wide receivers. The veteran is also coming off his worst game of the season, a performance in which he caught just one pass for negative three yards against Tampa Bay. Without knowing the full extent of the absence, managers will have to wait until Buffalo releases its list of inactives to make sure Shakir is playing. Luckily, as the first game of the week, there will be ample opportunity to pivot in another direction.

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Buffalo Bills wide receiver Joshua Palmer can safely be left out of lineups in most formats when his team travels to Houston to play the Texans for Week 12's Thursday Night Football game. The former Los Angeles Charger has been a disappointment in his first season with Buffalo, during which he has logged only 16 receptions and is still looking for his first touchdown. This week, Palmer will have the added challenge of the single worst matchup in football: Houston ranks No. 1 against PPR wide receivers. Though the status of fellow receiver Khalil Shakir (personal) is unknown, and Keon Coleman is coming off a healthy scratch last week, Palmer hasn't had a big enough role to rely upon for fantasy lineups.

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Cincinnati Bengals head coach Zac Taylor said Thursday morning that the club has not yet ruled out quarterback Joe Burrow (toe) from playing on Sunday against the New England Patriots, according to Paul Dehner of The Athletic. Taylor, who appeared on a Cincinnati radio show, said he wasn't ready to say whether Burrow would be able to return from his injury. "I'm not there yet," he said. "One day at practice isn't going to lead to that decision yet." The superstar quarterback has missed most of the 2025 season due to the injury, but he fully practiced on Wednesday, giving hope that he may return sooner than initially believed. For fantasy managers who held out for the long haul, Burrow's return would represent a major lineup upgrade as the playoffs draw near.

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Buffalo Bills running back James Cook III is set to face a tough Houston Texans' defense on Thursday night that has allowed just 87.1 rushing yards per game, which ranks third in the NFL. It could be tough sledding for Cook on Thursday against a stout Texans defense, but he remains a must-start in Week 12. Cook is averaging 115.8 scrimmage yards per game and has produced eight touchdowns over 10 contests. The 26-year-old back is enjoying his best season, and the Bills are sure to feature Cook on Thursday. Look for another strong showing and RB1 potential for Cook this week. Despite the brutal matchup, Cook should be in all fantasy lineups and is ranked 11th among all running backs for Week 12.

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Buffalo Bills kicker Matt Prater has continued to flash just enough potential in the team's high-powered offense to remain relevant in fantasy football. The 41-year-old will look to rack up double-digit points against the Houston Texans on Thursday night for the first time since Week 8. Prater has totaled just 13 points over his last three games. Meanwhile, the Texans are allowing just 5.1 points per game to opposing kickers, the lowest total in the league. With Josh Allen leading the way, expect the Bills to find the endzone multiple times, but Prater's value will come from field goal opportunities, which are shaky at best. Despite the tough matchup, Prater can be used as a streamer in Week 12 and is ranked 10th among all kickers in the latest RotoBaller rankings.

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Buffalo Bills quarterback Josh Allen is coming off a monster performance in last Sunday's 44-32 win over the Tampa Bay Buccaneers. He threw for 317 yards with three touchdowns and two interceptions while rushing for 40 yards on six rushing attempts and three more scores versus the Bucs. Allen will look to keep things rolling against the Houston Texans on Thursday night. Houston's defense is third-best in the NFL in passing yards allowed per game at 174, but Allen's ability to beat them with his feet gives him a high floor. The Texans' defense has held opponents to 20-or-fewer points in all but two matchups this season, to keep their struggling offense in ballgames. However, Allen's MVP-caliber season continues, and he remains a must-start and comes in as the second-ranked quarterback heading into Week 12 in the latest RotoBaller rankings.

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