Atlanta Falcons wide receiver Darnell Mooney made an immediate impact with Drake London (knee) out in the team's Week 12 win over the New Orleans Saints on Sunday. Although Mooney only had three targets in the 24-10 victory on the road, he made his three receptions count, leading the team with 74 receiving yards and finding the end zone for the first time in 2025. The 28-year-old's 74 yards were also a season high. Efficiency could be a problem going forward with quarterback Kirk Cousins taking over for the injured Michael Penix Jr. (knee) for the rest of the year, but Mooney could have more opportunities as Atlanta's WR1 with London dealing with a PCL sprain. London is considered week-to-week and could miss the team's Week 13 contest against the New York Jets. Coming into Sunday's game, Mooney had exactly one catch in three of the last four contests. However, he'll be in play again next week as a WR4/flex in fantasy if London misses a second straight game.

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Tampa Bay Buccaneers quarterback Baker Mayfield (shoulder) is doubtful to return to Sunday night's contest against the Los Angeles Rams at SoFi Stadium due to a left (non-throwing) shoulder injury, according to Tom Pelissero of NFL Network. Mayfield injured his left shoulder near the end of the first half of Week 12 and is unlikely to return in the second half. The 30-year-old veteran went 9-for-19 passing for 41 yards, one touchdown, and two interceptions in the first half, adding 19 rushing yards on four carries. Mayfield's second interception came on a Hail Mary attempt with time expiring in the second quarter. The Bucs were trailing 31-7 going into the second half, which could play into Tampa's decision to sit Mayfield for the entire second half. Teddy Bridgewater will take over the rest of the way. As of now, it's unclear if Mayfield's shoulder injury is serious enough to put him in danger of missing the Week 13 game against the Arizona Cardinals.

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Pittsburgh Steelers running back Kenneth Gainwell had his second straight big game in his team's 31-28 Week 12 loss to the Chicago Bears, recording 10 carries for 92 yards and six receptions for 30 yards on six targets. The 26-year-old has emerged as a featured player in the Pittsburgh passing game in recent weeks, recording 13 receptions on 14 targets over the last two games. Notably, fellow Steelers running back Jaylen Warren did not earn a target in Week 12. Gainwell also out-gained Warren 92 yards to 68 yards on the ground, despite logging eight fewer carries. While Pittsburgh is likely to continue featuring both backs, Gainwell may be eating into Warren's playing time with his recent performance. For the season, Gainwell is now averaging over five yards per touch. He's worthy of flex consideration for fantasy managers heading into a Week 13 matchup against the Buffalo Bills.

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Cleveland Browns rookie running back Dylan Sampson recorded 81 scrimmage yards and a touchdown on nine touches in his team's 24-10 Week 12 win over the Las Vegas Raiders. The 21-year-old delivered one of the biggest plays of the game in the fourth quarter when he took a short completion from Browns quarterback Shedeur Sanders and turned it into a 66-yard catch-and-run touchdown. Sampson has provided the majority of his production this season in the passing game. Across 11 games, he's recorded 23 catches for 185 yards and two touchdowns on 27 targets. Fellow Browns rookie running back Quinshon Judkins remains the early-down rushing workhorse in Cleveland, limiting Sampson's upside. However, he's flashed upside as a pass-catching back that could keep him on deep-league radars down the stretch of the fantasy season. Cleveland will host the San Francisco 49ers in Week 13.

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Arizona Cardinals quarterback Jacoby Brissett completed 33 of 49 pass attempts for 317 yards, one touchdown, and zero interceptions in his team's 27-24 overtime Week 12 loss to the Jacksonville Jaguars. Since taking over as the Cardinals' starting QB for the injured Kyler Murray (foot) in Week 6, Brissett has led one of the league's highest-volume passing attacks. Over his last three games alone, the 32-year-old has attempted a whopping 150 passes. The consistently high volume of throws has helped Brissett put up some impressive counting stats. Across eight games (six starts) in 2025, he's thrown for 1,867 yards, 11 touchdowns, and three interceptions. As long as the Cardinals continue to turn to the air at a high rate, Brissett warrants starting consideration from fantasy managers, even in single-QB formats. Arizona will travel to Tampa Bay to take on the Buccaneers in Week 13.

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Las Vegas Raiders running back Ashton Jeanty had an underwhelming day on the ground in his team's Week 12 loss to the Cleveland Browns, recording just 50 rushing yards on 17 carries. However, the 21-year-old saved his fantasy production with a monster day as a receiver, recording eight catches for 58 yards and a touchdown on eight targets. With the Raiders' depleted offensive line struggling to open up holes in the ground game, receiving work has become an increasingly important part of Jeanty's repertoire in recent weeks. Across his last four games, Jeanty has hauled in 22 receptions for 135 yards and two touchdowns on 26 targets. He's been targeted eight times in each of the last two weeks. The Raiders' overall inability to consistently move the ball limits Jeanty's ceiling, but he still profiles as a high-volume fantasy RB2 heading into a Week 13 matchup with the Los Angeles Chargers.

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Cleveland Browns DE Myles Garrett posted five total stops, including four of the solo variety, with three sacks, four tackles for loss and a game-high six quarterback hits. He has 18 sacks on the season, 4.5 short of the NFL record with six games remaining.

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Philadelphia Eagles wide receiver A.J. Brown delivered a vintage performance in his team's 24-21 Week 12 loss to the Dallas Cowboys, hauling in eight receptions for 110 yards and a touchdown on 10 targets. The 28-year-old has spent most of the 2025 season publicly agitated by his role in Philadelphia's underwhelming pass game. However, Brown has now seen double-digit targets in each of the last two weeks. Across 10 games for the season, he's recorded 46 catches for 567 yards and four touchdowns on 75 targets. Brown's increased involvement in recent games could be a sign that he is getting back on the same page with Eagles quarterback Jalen Hurts. While Brown hasn't provided the consistent production fantasy managers were hoping for before the start of the season, he remains a starting fantasy wide receiver heading into a Week 13 matchup against the Chicago Bears.

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Cleveland Browns TE David Njoku went without a catch or target in Week 12 against the Las Vegas Raiders.

Fantasy Spin: Njoku has been forced to reserve status in the Cleveland offense, as rookie Harold Fannin Jr. seems to have been the preferred tight end ever since training camp. For now, Njoku should be cut loose, as he has gone from fantasy TE1 to non-existent in less than a calendar year.

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Arizona Cardinals QB Jacoby Brissett completed 33 of his 49 pass attempts for 317 yards and a touchdown and rushed for 20 yards on three carries in a 27-24 loss to the Jacksonville Jaguars in Week 12.

Fantasy Spin: Brissett has now topped 300 passing yards in three of his six starts this season, and he has yet to throw for fewer than 250 yards as the starter. On the flip side, he did fail to throw multiple touchdowns for the first time since taking over under center, but Brissett is locked in as a high-end QB2 with QB1 upside.

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The Kansas City Chiefs are signing former Houston Texans running back Dameon Pierce to their practice squad, according to NFL insider Jordan Schultz. He was recently cut loose by the Texans. Once a promising, young running back, Pierce endured a fall from grace and eventually became the odd man out in Houston's backfield. He went from having over 1,100 yards and five touchdowns as a rookie in 2022 to just 26 yards on 10 carries through four games this year. Although he's no longer an impact name in the NFL or fantasy football, the Chiefs hope they can tap into some of his potential, starting by getting him reps on the practice squad. Kansas City needed running back depth with Isiah Pacheco (knee) sidelined and Elijah Mitchell (healthy scratch) losing relevance. It's unlikely that Pierce will have any sort of short-term fantasy value in Kansas City, but the fresh start is promising nonetheless.

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Jacksonville Jaguars running back Travis Etienne Jr. rushed for 86 yards on 15 carries during Sunday's Week 12 victory over the Arizona Cardinals. He also caught three of his four targets for 30 receiving yards and a touchdown. After a bit of a lull earlier in the season, Etienne has bounced back as a highly effective RB1 in fantasy football ever since his bye week. In four games since the bye, he has 301 rushing yards, 80 receiving yards, and four touchdowns while ranking as the overall RB6 in PPR leagues during that span. Unlike last week, Etienne was able to fend off a strong game from backfield-mate Bhayshul Tuten this Sunday. It appears as though Etienne still has a firm grasp on the lead-back role in Jacksonville, keeping him in the top-10 range for next week's matchup against a struggling Tennessee Titans run defense.

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Dallas Cowboys quarterback Dak Prescott completed 23 of 36 pass attempts for 354 passing yards, two passing touchdowns, and one interception during Sunday's Week 12 win over the Philadelphia Eagles. He also had nine rushing yards and one rushing touchdown. The Cowboys were held scoreless until the final seconds of the first half, when Dallas finally started to chip into its 21-0 deficit. From there, Prescott led three touchdown drives and ultimately got the Cowboys in position to kick a game-winning field goal in overtime. The 32-year-old has seven total touchdowns over his last two games and ranks as the overall QB5 in fantasy scoring so far. He should continue to be started in all leagues ahead of an intriguing showdown against the Kansas City Chiefs on Thanksgiving Day in Week 13.

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Dallas Cowboys wide receiver George Pickens caught all nine of his targets for 146 yards and one touchdown during Sunday's Week 12 win over the Philadelphia Eagles. The 24-year-old has drastically exceeded expectations in his first season with Dallas; not only does he have higher stats than superstar teammate CeeDee Lamb, but he's also been more productive than nearly every receiver in the league. He currently ranks as the overall WR3 in PPR leagues this season, and he shows no signs of slowing down. Pickens' next chance of producing will come in Week 13 against the Kansas City Chiefs on Thanksgiving. He continues to be a must-start WR1 in all fantasy leagues despite Kansas City allowing the second-fewest points to wide receivers this year.

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New Orleans Saints running back Alvin Kamara (knee) will undergo an MRI as the team continues to evaluate his status, according to Nick Underhill of New Orleans Football. Kamara exited during the first half of Sunday's loss against the Atlanta Falcons and was quickly ruled out. He finished the game with just five touches and 15 scrimmage yards. New Orleans can't exactly afford another long-term running back injury, as Kendre Miller (knee) is already on injured reserve. If Kamara misses extended time, the Saints will be forced to proceed with rookie Devin Neal as their lead back. Neal has intriguing draft capital as a sixth-round pick, but he had just 17 total touches prior to this week. Kamara will have seven days to get healthy before the Saints return to action against the Miami Dolphins next Sunday.

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New York Giants QB Jameis Winston completed 18 of his 36 passes for 366 yards, two touchdowns and an interception in a 34-27 loss to the Detroit Lions in Week 12. He also ran four times for 13 yards and caught a 33-yard touchdown pass.

Fantasy Spin: Winston was making his second start in place of Jaxson Dart, and he certainly put on a show. Winston has never been afraid to push the ball down the field, but his playing style has often led to better fantasy results than results for his actual team. If Dart misses more time, Winston can be viewed as a high-risk, high-reward QB2.

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Detroit Lions QB Jared Goff was 28-of-42 for 279 yards with two touchdowns and an interception in a Week 12 OT win over the New York Giants.

Fantasy Spin: Goff topped 250 yards passing for the fourth straight week and threw for multiple touchdowns in his seventh game. He has 23 touchdowns and five interceptions this season. His '25 numbers are solid but not as good as '24 and because he's not a running threat, he's not a certain QB1 in most fantasy formats. However, you know what you're getting with Goff if you put him in the lineup.

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Philadelphia Eagles quarterback Jalen Hurts completed 27 of his 39 pass attempts for 289 yards, one touchdown, and zero interceptions during Sunday's Week 12 loss against the Dallas Cowboys. He also had seven rushing attempts for a team-high 33 rushing yards, plus two additional touchdowns on the ground. Although the Eagles lost, fantasy managers will chalk this up to a productive game for the 27-year-old, especially since he hadn't scored multiple touchdowns in a single game since Week 8. In addition to his touchdown total and rushing yardage, it was very encouraging to see Hurts complete nearly 70% of his passes for almost 300 yards. He should be trusted as a strong QB1 option heading into Week 13 against the Chicago Bears.

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Seattle Seahawks quarterback Sam Darnold completed 16 of his 26 pass attempts for 244 yards, two touchdowns, and zero interceptions during Sunday's Week 12 win over the Tennessee Titans. Darnold had seven turnovers over his last two games coming into this week, so it was refreshing to see him play clean, turnover-free football, albeit in a softer matchup against a subpar Titans defense. The veteran quarterback had his best fantasy performance since Week 9 and will remain in the mix as a high-end QB2 for Week 13 against the Minnesota Vikings in an exciting revenge game scenario. With that being said, Seattle could opt to go run-heavy against the Vikings, taking the ball out of Darnold's hands from time to time. Minnesota surrendered 146 rushing yards and two rushing touchdowns to the Packers in Week 12, whereas Jordan Love only threw for 139 yards and no scores.

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Tampa Bay Buccaneers wide receiver Chris Godwin (fibula) is officially active for Sunday Night Football against the Los Angeles Rams in Week 12. He had been listed as questionable after practicing in a limited capacity this past Friday. Godwin has appeared in just two games this season, registering three catches for 26 yards in each of them. His latest absence spanned five games, but he's returning at a perfect time for the Bucs, who'll need all the help they can get against a strong Rams defense. Los Angeles has allowed the fourth-fewest touchdowns and 12th-fewest fantasy points to wide receivers in 2025. Godwin ranks as an RB3/flex in his role behind Emeka Egbuka.

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